ZFIN ID: ZDB-GENE-060616-382
Gene Name: integrin, alpha V
Gene Symbol: itgav    Nomenclature History

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Previous Name: zgc:136222 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Involved in several processes, including Kupffer's vesicle development; axis elongation involved in somitogenesis; and cell migration involved in gastrulation. Localizes to the integrin complex. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and acute myeloid leukemia. Is expressed in several structures, including axis; diencephalon; head; pleuroperitoneal region; and post-vent vasculature. Orthologous to human ITGAV (integrin subunit alpha V).
Genome Resources: Alliance (1),  Gene:100151255 (1),  Ensembl(GRCz11):ENSDARG00000006314 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la016467Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31703 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34569 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41365 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-itgav N/A 3
    MO2-itgav N/A 1
    MO3-itgav N/A 1
    MO4-itgav N/A 1
    MO5-itgav N/A 3
    DISEASE ASSOCIATED WITH itgav HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH itgav VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Cellular Component integrin complex (more)
    Molecular Function protein binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
    Domain IPR013649 Integrin alpha-2
    Family IPR000413 Integrin alpha chain
    Homologous_superfamily IPR028994 Integrin alpha, N-terminal
    Homologous_superfamily IPR032695 Integrin domain superfamily
    Repeat IPR013517 FG-GAP repeat
    Repeat IPR013519 Integrin alpha beta-propellor
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA itgav-201 (1)    Ensembl 4328
    ncRNA itgav-002 (1)    Ensembl 1338
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM itgav No data available
    MARKER RELATIONSHIPS
    itgav Contained in: [BAC] DKEY-69O16 (1) (order this)
    itgav Encodes: [cDNA] MGC:136222 (1), MGC:195124 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001033721 (1) 4301 nt
    Genomic GenBank:CU468956 (1) 156034 nt
    Select Tool
    Polypeptide UniProtKB:B3DJQ3 (1) 1045 aa
    Sequence Information (all 20)
    ORTHOLOGY for itgav ( Chr: 9 )
    CITATIONS (40)