Gene

top1a

ID
ZDB-GENE-060616-217
Name
DNA topoisomerase Ia
Symbol
top1a Nomenclature History
Previous Names
  • top1l
  • wu:fc66a02
  • zgc:136349
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to enable DNA topoisomerase type I (single strand cut, ATP-independent) activity. Predicted to be involved in DNA replication; chromosome organization; and chromosome segregation. Predicted to be located in chromosome. Predicted to be active in nucleolus. Orthologous to human TOP1 (DNA topoisomerase I).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With top1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
DNA topoisomerase I, camptothecin-resistant
Associated With top1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR018521 DNA topoisomerase I, active site
Domain IPR008336 DNA topoisomerase I, DNA binding, eukaryotic-type
Domain IPR013499 DNA topoisomerase I, eukaryotic-type
Domain IPR013500 DNA topoisomerase I, catalytic core, eukaryotic-type
Domain IPR025834 Topoisomerase I C-terminal domain
Family IPR001631 DNA topoisomerase I
Homologous_superfamily IPR011010 DNA breaking-rejoining enzyme, catalytic core
Homologous_superfamily IPR013030 DNA topoisomerase I, DNA binding, N-terminal domain 2
Homologous_superfamily IPR013034 DNA topoisomerase I, DNA binding, N-terminal domain 1
Homologous_superfamily IPR014711 DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type
Homologous_superfamily IPR014727 DNA topoisomerase I, catalytic core, alpha/beta subdomain
Homologous_superfamily IPR036202 DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily
Domain Details Per Protein
Protein Length DNA breaking-rejoining enzyme, catalytic core DNA topoisomerase I DNA topoisomerase I, active site DNA topoisomerase I, catalytic core, alpha/beta subdomain DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type DNA topoisomerase I, catalytic core, eukaryotic-type DNA topoisomerase I, DNA binding, eukaryotic-type DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily DNA topoisomerase I, DNA binding, N-terminal domain 1 DNA topoisomerase I, DNA binding, N-terminal domain 2 DNA topoisomerase I, eukaryotic-type Topoisomerase I C-terminal domain
UniProtKB:Q6IQI8 469
UniProtKB:Q1ED17 758
UniProtKB:A0A0R4IST9 94
UniProtKB:Q504F2 321
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations