Gene
top1a
- ID
- ZDB-GENE-060616-217
- Name
- DNA topoisomerase Ia
- Symbol
- top1a Nomenclature History
- Previous Names
-
- top1l
- wu:fc66a02
- zgc:136349
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have DNA topoisomerase type I (single strand cut, ATP-independent) activity. Predicted to be involved in several processes, including DNA replication; DNA topological change; and chromatin remodeling. Predicted to localize to nucleolus and replication fork protection complex. Orthologous to human TOP1 (DNA topoisomerase I).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6898978 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| DNA topoisomerase I, camptothecin-resistant |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018521 | DNA topoisomerase I, active site |
| Domain | IPR008336 | DNA topoisomerase I, DNA binding, eukaryotic-type |
| Domain | IPR013499 | DNA topoisomerase I, eukaryotic-type |
| Domain | IPR013500 | DNA topoisomerase I, catalytic core, eukaryotic-type |
| Domain | IPR025834 | Topoisomerase I C-terminal domain |
| Domain | IPR048045 | DNA topoisomerase I, DNA-binding domain |
| Family | IPR001631 | DNA topoisomerase I |
| Family | IPR051062 | DNA topoisomerase IB |
| Homologous_superfamily | IPR011010 | DNA breaking-rejoining enzyme, catalytic core |
| Homologous_superfamily | IPR013030 | DNA topoisomerase I, DNA binding, N-terminal domain 2 |
| Homologous_superfamily | IPR013034 | DNA topoisomerase I, DNA binding, N-terminal domain 1 |
| Homologous_superfamily | IPR014711 | DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type |
| Homologous_superfamily | IPR014727 | DNA topoisomerase I, catalytic core, alpha/beta subdomain |
| Homologous_superfamily | IPR036202 | DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | DNA breaking-rejoining enzyme, catalytic core | DNA topoisomerase I | DNA topoisomerase I, active site | DNA topoisomerase IB | DNA topoisomerase I, catalytic core, alpha/beta subdomain | DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type | DNA topoisomerase I, catalytic core, eukaryotic-type | DNA topoisomerase I, DNA-binding domain | DNA topoisomerase I, DNA binding, eukaryotic-type | DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily | DNA topoisomerase I, DNA binding, N-terminal domain 1 | DNA topoisomerase I, DNA binding, N-terminal domain 2 | DNA topoisomerase I, eukaryotic-type | Topoisomerase I C-terminal domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q1ED17
|
758 |
Interactions and Pathways
No data available
Plasmids
No data available