Gene

arhgef1

ID

ZDB-GENE-060616-136

Name

Rho guanine nucleotide exchange factor (GEF) 1

Symbol

arhgef1 Nomenclature History

Previous Names

arhgef1b (1)
im:7155372
zgc:136551

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have G protein-coupled receptor binding activity; GTPase activator activity; and Rho guanyl-nucleotide exchange factor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and intracellular signal transduction. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is expressed in several structures, including adaxial cell; immature eye; nervous system; neural plate; and pericardial region. Orthologous to human ARHGEF1 (Rho guanine nucleotide exchange factor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7155372 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arhgef1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
immunodeficiency 62	Alliance	?Immunodeficiency 62	618459

Associated With arhgef1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR015212	Regulator of G protein signalling-like domain
Domain	IPR037887	p115RhoGEF, RGS domain
Domain	IPR041020	ARHGEF1-like, PH domain
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036305	RGS domain superfamily
Homologous_superfamily	IPR044926	RGS, subdomain 2

Domain Details Per Protein

Protein	Length	ARHGEF1-like, PH domain	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	Guanine-nucleotide dissociation stimulator, CDC24, conserved site	p115RhoGEF, RGS domain	PH-like domain superfamily	Pleckstrin homology domain	Regulator of G protein signalling-like domain	RGS domain superfamily	RGS, subdomain 2
UniProtKB:A0A8M9NZA7 InterPro	1071
UniProtKB:A0A8M9PMH6 InterPro	1002
UniProtKB:A0A8M6YTG6 InterPro	1061
UniProtKB:A0A8M9PD45 InterPro	1081
UniProtKB:A0A8M9PD48 InterPro	1026
UniProtKB:F1Q4Y0 InterPro	1005
UniProtKB:A0A8M9P7X6 InterPro	1053
UniProtKB:A0A8M9PJI7 InterPro	862
UniProtKB:A0A8M9P7X5 InterPro	1082
UniProtKB:A0A8M9PJI2 InterPro	1073
UniProtKB:A0A8M9PMH2 InterPro	1078