header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-060607-11
Gene Name: endothelial PAS domain protein 1b
Gene Symbol: epas1b    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: epas1, hif-2a (1), hif-2ab (1), HIF2A (1), wu:fq36f01

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Exhibits transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including digestive system development; embryonic liver development; and hematopoietic stem cell differentiation. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in familial erythrocytosis 4; lung non-small cell carcinoma; polycythemia; and pulmonary hypertension. Is expressed in several structures, including cardiovascular system; digestive system; musculature system; nervous system; and pleuroperitoneal region. Orthologous to human EPAS1 (endothelial PAS domain protein 1).
Genome Resources: Alliance (1),  Gene:555192 (1),  Ensembl(GRCz11):ENSDARG00000057671 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
bns232 Indel Exon 3 Frameshift, Premature Stop TALEN
f172jy Small Deletion Exon 3 Frameshift TALEN
la018754Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa814 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35421 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-epas1b N/A 5
    MO2-epas1b N/A 1
    MO3-epas1b N/A 2
    TALEN1-epas1b
    1
    TALEN2-epas1b 2
    TALEN3-epas1b 1
    DISEASE ASSOCIATED WITH epas1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    familial erythrocytosis 4 Alliance Erythrocytosis, familial, 4 611783
    DISEASE ASSOCIATED WITH epas1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hematopoietic stem cell differentiation (more)
    Cellular Component nucleus (more)
    Molecular Function transcription regulatory region sequence-specific DNA binding (more)
    GO Terms (all 18)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA epas1b-201 (1)    Ensembl 8581
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM epas1b No data available
    MARKER RELATIONSHIPS
    epas1b Contained in: [BAC] CH211-243F3 (1) (order this)
    epas1b Encodes: [EST] fq36f01 (1) (order this)
    [cDNA] MGC:194939 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001039806 (1) 3148 bp
    Genomic GenBank:BX248102 (1) 150473 bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8QI31 (1) 836 aa
    Sequence Clusters UniGene:83091 (1)
    Sequence Information (all 16)
    ORTHOLOGY for epas1b ( Chr: 13 )
    CITATIONS (52)