ZFIN ID: ZDB-GENE-060531-91
Gene Name: natriuretic peptide receptor 3
Gene Symbol: npr3    Nomenclature History

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Previous Names: im:7138418, si:dkey-199l1.2 (1), zgc:158440

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Involved in cardiac muscle cell proliferation. Predicted to localize to integral component of membrane. Is expressed in several structures, including heart; hypochord; nervous system; neural tube; and renal system. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPR3 (natriuretic peptide receptor 3).
Genome Resources: Alliance (1),  Gene:569395 (1),  Ensembl(GRCz11):ENSDARG00000035253 (1)
GENE EXPRESSION
All Expression Data: 5 figures from 2 publications
Directly Submitted Expression Data: 4 figures (5 images) from Thisse et al., 2004 [IMAGE:7138418]
Wild-type Stages, Structures: Segmentation:5-9 somites (11.66h-14.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la015689Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la025074Tg Transgenic Insertion Unknown Unknown DNA
    la029106Tg Transgenic Insertion Unknown Unknown DNA
    sa6997 Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-npr3 N/A 1
    DISEASE ASSOCIATED WITH npr3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?Hypertension, salt-resistant
    DISEASE ASSOCIATED WITH npr3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cardiac muscle cell proliferation (more)
    Cellular Component integral component of membrane (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA npr3-201 (1)    Ensembl 3297
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM npr3 No data available
    MARKER RELATIONSHIPS
    npr3 Contained in: [BAC] DKEY-199L1 (1) (order this)
    npr3 Encodes: [EST] IMAGE:7138418 (1)
    [cDNA] MGC:158440 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001102673 (1) 3350 nt
    Genomic GenBank:BX005419 (1) 179474 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8RSJ1 (1) 503 aa
    Sequence Information (all 14)
    ORTHOLOGY for npr3 ( Chr: 5 )
    CITATIONS (26)