ZFIN ID: ZDB-GENE-060531-44
Gene Name: calcium channel, voltage-dependent, N type, alpha 1B subunit, a
Gene Symbol: cacna1ba    Nomenclature History

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Previous Names: cacna1b (1), CACNA1Bb (1), si:ch211-238e12.1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have voltage-gated calcium channel activity. Predicted to be involved in calcium ion import and chemical synaptic transmission. Predicted to localize to voltage-gated calcium channel complex. Is expressed in atrium; brain; cardiac ventricle; and liver. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome and dystonia 23. Orthologous to human CACNA1B (calcium voltage-gated channel subunit alpha1 B).
Genome Resources: Alliance (1),  Gene:555941 (1),  Ensembl(GRCz11):ENSDARG00000021735 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la015633Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1562 Point Mutation Unknown Premature Stop ENU
    sa20442 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20443 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26487 Point Mutation Unknown Splice Site ENU
    sa31446 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33621 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33622 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40450 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40451 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40452 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45208 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cacna1ba HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Neurodevelopmental disorder with seizures and nonepileptic hyperkinetic movements 618497
    DISEASE ASSOCIATED WITH cacna1ba VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process calcium ion transmembrane transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium channel activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cacna1ba-201 (1)    Ensembl 6939
    cacna1ba-202 (1)    Ensembl 6813
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cacna1ba No data available
    MARKER RELATIONSHIPS
    cacna1ba Contained in: [BAC] CH211-238E12 (1), DKEY-225K7 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001114548 (1) 6939 nt
    Genomic GenBank:BX571772 (1) 125812 nt
    Select Tool
    Polypeptide UniProtKB:A2BHF4 (1) 2312 aa
    Sequence Information (all 45)
    ORTHOLOGY for cacna1ba ( Chr: 5 )
    CITATIONS (29)