ZFIN ID: ZDB-GENE-060531-43
Gene Name: leucine rich repeat containing 8 VRAC subunit Ab
Gene Symbol: lrrc8ab    Nomenclature History

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Previous Name: si:ch211-236k19.7

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine phosphatase activity and volume-sensitive anion channel activity. Predicted to be involved in aspartate transmembrane transport; cellular response to osmotic stress; and taurine transport. Predicted to localize to cytoplasm; integral component of plasma membrane; and ion channel complex. Human ortholog(s) of this gene implicated in agammaglobulinemia and agammaglobulinemia 5. Orthologous to several human genes including LRRC8A (leucine rich repeat containing 8 VRAC subunit A).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000052155 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa16642 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-lrrc8ab
    1
    CRISPR2-lrrc8ab
    1
    CRISPR3-lrrc8ab
    1
    CRISPR4-lrrc8ab
    1
    MO1-lrrc8ab N/A 1
    MO2-lrrc8ab N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH lrrc8ab HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    agammaglobulinemia 5 Alliance ?Agammaglobulinemia 5 613506
    DISEASE ASSOCIATED WITH lrrc8ab VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component integral component of membrane (more)
    GO Terms (all 2)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lrrc8ab-202 (1)    Ensembl 2717
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lrrc8ab No data available
    MARKER RELATIONSHIPS
    lrrc8ab Contained in: [BAC] CH211-236K19 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    Genomic GenBank:BX255921 (1) 142918 nt
    Select Tool
    Polypeptide UniProtKB:A2BF98 (1) 796 aa
    ORTHOLOGY for lrrc8ab ( Chr: 5 )
    CITATIONS (14)