ZFIN Gene: pcsk5a

ZFIN ID: ZDB-GENE-060531-130

ZFIN ID: ZDB-GENE-060531-130

Gene Name:

proprotein convertase subtilisin/kexin type 5a

Gene Symbol:

pcsk5a Nomenclature History

Previous Names:

pc5.1 (1), pcsk5.1 (1), PCSK5/6a, si:dkey-267i17.1 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 5 Mapping Details/Browsers

Description:

Predicted to have serine-type endopeptidase activity. Involved in anterior lateral line development and neuromast development. Predicted to localize to the integral component of Golgi membrane and trans-Golgi network. Is expressed in several structures, including eye; lateral line system; liver; otic vesicle; and pleuroperitoneal region. Orthologous to human PCSK5 (proprotein convertase subtilisin/kexin type 5).

Genome Resources:

Alliance (1), Gene:571235 (1), Ensembl(GRCz11):ENSDARG00000067537 (2)

GENE EXPRESSION
All Expression Data:	3 figures from 2 publications
Wild-type Stages, Structures:	Blastula:1k-cell (3.0h-3.33h) to Adult (90d-730d, breeding adult)
	anterior lateral line primordium brain dorsal lateral line neuromast eye gill gonad integument intestine kidney lateral line primordium liver neuromast neuromast hair cell neuromast support cell otic vesicle anterior region otic vesicle posterior region otic vesicle post-vent region posterior lateral line neuromast posterior lateral line primordium whole organism

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa397	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa8843	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa9667	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa14669	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa20536	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa33720	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa38507	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-pcsk5a	N/A	1
MO2-pcsk5a	N/A	1

PHENOTYPE

Data:	3 figures from Chitramuthu et al., 2010
Observed in:	lateral line neuromast neuromast development post-vent region trunk whole organism

DISEASE ASSOCIATED WITH pcsk5a HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH pcsk5a VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	anterior lateral line development (more)
Cellular Component	integral component of membrane (more)
Molecular Function	hydrolase activity (more)

GO Terms (all 13)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR000209 (1) InterPro:IPR000742 (1) InterPro:IPR001368 (1) InterPro:IPR002884 (1) InterPro:IPR006212 (1) InterPro:IPR008979 (1) InterPro:IPR009030 (1) InterPro:IPR011641 (1) InterPro:IPR015500 (1) InterPro:IPR022398 (1) InterPro:IPR023827 (1) InterPro:IPR023828 (1) InterPro:IPR032778 (1) InterPro:IPR032815 (1) InterPro:IPR034182 (1) InterPro:IPR036852 (1) InterPro:IPR038466 (1)	PROSITE:PS00136 (1) PROSITE:PS00137 (1) PROSITE:PS00138 (1) PROSITE:PS50050 (1) PROSITE:PS51829 (1)	Pfam:PF00082 (1) Pfam:PF01483 (1) Pfam:PF14843 (1) Pfam:PF16470 (1)

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	pcsk5a-201 (1)	5466	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM pcsk5a No data available

MARKER RELATIONSHIPS

pcsk5a Contained in:

[BAC] DKEY-267I17 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_001077582 (1)	3495 bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX571945 (1)	192769 bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A2BHH6 (1)	1821 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:74506 (1)

Sequence Information (all 13)

ORTHOLOGY for pcsk5a ( Chr: 5 )

CITATIONS (26)

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