Gene

pcsk5a

ID
ZDB-GENE-060531-130
Name
proprotein convertase subtilisin/kexin type 5a
Symbol
pcsk5a Nomenclature History
Previous Names
  • pc5.1 (1)
  • pcsk5.1 (1)
  • PCSK5/6a
  • si:dkey-267i17.1 (1)
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have serine-type endopeptidase activity. Involved in anterior lateral line development and neuromast development. Predicted to localize to integral component of Golgi membrane and trans-Golgi network. Is expressed in several structures, including eye; lateral line system; liver; otic vesicle; and pleuroperitoneal region. Orthologous to human PCSK5 (proprotein convertase subtilisin/kexin type 5).
Genome Resources
Note
None
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Chitramuthu et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pcsk5a Human Ortholog
No data available
Associated With pcsk5a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR022398 Peptidase S8, subtilisin, His-active site
Active_site IPR023827 Peptidase S8, subtilisin, Asp-active site
Active_site IPR023828 Peptidase S8, subtilisin, Ser-active site
Domain IPR000209 Peptidase S8/S53 domain
Domain IPR000742 EGF-like domain
Domain IPR001368 TNFR/NGFR cysteine-rich region
Domain IPR002884 P domain
Domain IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
Domain IPR032778 Growth factor receptor domain 4
Domain IPR032815 Peptidase S8, pro-domain
Domain IPR034182 Kexin/furin catalytic domain
Family IPR015500 Peptidase S8, subtilisin-related
Homologous_superfamily IPR008979 Galactose-binding-like domain superfamily
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR036852 Peptidase S8/S53 domain superfamily
Homologous_superfamily IPR038466 Peptidase S8, pro-domain superfamily
Repeat IPR006212 Furin-like repeat
Domain Details Per Protein
Protein Length EGF-like domain Furin-like repeat Galactose-binding-like domain superfamily Growth factor receptor cysteine-rich domain superfamily Growth factor receptor domain 4 Kexin/furin catalytic domain P domain Peptidase S8, pro-domain Peptidase S8, pro-domain superfamily Peptidase S8/S53 domain Peptidase S8/S53 domain superfamily Peptidase S8, subtilisin, Asp-active site Peptidase S8, subtilisin, His-active site Peptidase S8, subtilisin-related Peptidase S8, subtilisin, Ser-active site TNFR/NGFR cysteine-rich region Tyrosine-protein kinase ephrin type A/B receptor-like
UniProtKB:A2BHH6 1821
UniProtKB:F1R175 1093
UniProtKB:Q069L1 1093
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations