Gene

pappab

ID

ZDB-GENE-060526-71

Name

pregnancy-associated plasma protein A, pappalysin 1b

Symbol

pappab Nomenclature History

Previous Names

si:ch211-196f15.1

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Exhibits peptidase activity. Involved in chordate embryonic development. Human ortholog(s) of this gene implicated in myocardial infarction. Is expressed in several structures, including digestive system; muscle; nervous system; pleuroperitoneal region; and skeletal tissue. Orthologous to human PAPPA (pappalysin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Kjaer-Sorensen et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pappab Human Ortholog

No data available

Associated With pappab Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000436	Sushi/SCR/CCP domain
Domain	IPR000800	Notch domain
Domain	IPR006558	LamG-like jellyroll fold
Domain	IPR008754	Peptidase M43, pregnancy-associated plasma-A
Family	IPR043543	Pappalysin-1/2
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR024079	Metallopeptidase, catalytic domain superfamily
Homologous_superfamily	IPR035976	Sushi/SCR/CCP superfamily
Repeat	IPR011936	Myxococcus cysteine-rich repeat

Domain Details Per Protein

Protein	Length	Concanavalin A-like lectin/glucanase domain superfamily	LamG-like jellyroll fold	Metallopeptidase, catalytic domain superfamily	Myxococcus cysteine-rich repeat	Notch domain	Pappalysin-1/2	Peptidase M43, pregnancy-associated plasma-A	Sushi/SCR/CCP domain	Sushi/SCR/CCP superfamily
UniProtKB:A0A8M3ASU7 InterPro	1633
UniProtKB:M1WXG8 InterPro	1624

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pappab-202 (1) Ensembl	Havana	599 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	pappab-203 (1) Ensembl	Havana	4821 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations