ZFIN ID: ZDB-GENE-060526-274
Gene Name: solute carrier family 4 member 4a
Gene Symbol: slc4a4a    Nomenclature History

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Previous Names: slc4a4, id:ibd2520, NBC1 (1), NBCe1 (1), si:dkey-256m11.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Exhibits sodium:bicarbonate symporter activity. Predicted to be involved in bicarbonate transport and regulation of intracellular pH. Predicted to localize to integral component of membrane. Is expressed in several structures, including central nervous system; eye; intermediate mesoderm; optic cup; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to human SLC4A4 (solute carrier family 4 member 4).
Genome Resources: Alliance (1),  Gene:568631 (1),  Ensembl(GRCz11):ENSDARG00000013730 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6999 Point Mutation Unknown Splice Site ENU
sa30864 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40542 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-slc4a4a N/A 1
    PHENOTYPE
    Data: Fig. 4 from Sussman et al., 2009
    Observed in:
    DISEASE ASSOCIATED WITH slc4a4a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Renal tubular acidosis, proximal, with ocular abnormalities 604278
    DISEASE ASSOCIATED WITH slc4a4a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anion transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function sodium:bicarbonate symporter activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA slc4a4a-202 (1)    Ensembl 2810
    ncRNA slc4a4a-002 (1)    Ensembl 499
    slc4a4a-003 (1)    Ensembl 542
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM slc4a4a No data available
    MARKER RELATIONSHIPS
    slc4a4a Contained in: [BAC] CH211-72M2 (1), CH211-254O18 (1), DKEY-256M11 (1) (order this)
    [Fosmid] CH1073-449N9 (1)
    slc4a4a Encodes: [EST] ibd2520
    [cDNA] MGC:193793 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001034984 (1) 4739 nt
    Genomic GenBank:BX294131 (1) 164141 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8PYB9 (1) 1114 aa
    Sequence Information (all 37)
    ORTHOLOGY for slc4a4a ( Chr: 5 )
    CITATIONS (42)