ZFIN ID: ZDB-GENE-060526-261
Gene Name: transmembrane channel-like 1
Gene Symbol: tmc1    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: si:dkey-229d2.1

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have mechanosensitive ion channel activity. Predicted to be involved in detection of mechanical stimulus involved in sensory perception of sound and vestibular reflex. Localizes to stereocilium bundle. Is expressed in anterior crista; inner ear; lateral crista; neuromast; and posterior crista. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 36; autosomal recessive nonsyndromic deafness 7; and sensorineural hearing loss. Orthologous to human TMC1 (transmembrane channel like 1).
Genome Resources: Alliance (1), 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa807 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11855 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26471 Point Mutation Unknown Premature Stop ENU
    sa40426 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tmc1
    2
    CRISPR2-tmc1
    1
    CRISPR3-tmc1
    3
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tmc1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant nonsyndromic deafness 36 Alliance Deafness, autosomal dominant 36 606705
    autosomal recessive nonsyndromic deafness 7 Alliance Deafness, autosomal recessive 7 600974
    DISEASE ASSOCIATED WITH tmc1 VIA EXPERIMENTAL MODELS No data available
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tmc1-202 (1)    Ensembl 2499
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tmc1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(myo6b:tmc1-EGFP) myo6b EGFPtmc1 Danio rerio 1 3
    MARKER RELATIONSHIPS
    tmc1 Contained in: [BAC] DKEY-229D2 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    Genomic GenBank:BX296526 (1) 179086 nt
    Select Tool
    Polypeptide UniProtKB:F1QFU0 (1) 720 aa
    ORTHOLOGY for tmc1 ( Chr: 5 )
    CITATIONS (24)