Community Action Needed: Please respond to the NIH RFI
Gene

atxn2

ID
ZDB-GENE-060526-217
Name
ataxin 2
Symbol
atxn2 Nomenclature History
Previous Names
  • si:dkey-165i4.1 (1)
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable RNA binding activity. Predicted to be involved in stress granule assembly. Predicted to be active in cytoplasmic stress granule. Is expressed in gut; motor neurons; and spinal cord. Human ortholog(s) of this gene implicated in late onset Parkinson's disease and spinocerebellar ataxia type 2. Orthologous to human ATXN2 (ataxin 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Laboissonniere et al., 2018
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With atxn2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
late onset Parkinson's disease Alliance {Parkinson disease, late-onset, susceptibility to} 168600
spinocerebellar ataxia type 2 Alliance Spinocerebellar ataxia 2 183090
spinocerebellar ataxia type 2 Alliance {Amyotrophic lateral sclerosis, susceptibility to, 13} 183090
Associated With atxn2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR009604 LsmAD domain
Domain IPR009818 Ataxin-2, C-terminal
Domain IPR025852 Ataxin 2, SM domain
Family IPR033093 Ataxin-2
Domain Details Per Protein
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations