Gene

adamts8a

ID

ZDB-GENE-060526-202

Name

ADAM metallopeptidase with thrombospondin type 1 motif, 8a

Symbol

adamts8a Nomenclature History

Previous Names

ADAMTS8d (1)
si:dkey-127j5.2

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have metalloendopeptidase activity and zinc ion binding activity. Predicted to be involved in proteolysis. Predicted to localize to collagen-containing extracellular matrix. Is expressed in several structures, including digestive system; eye; gonad; heart; and immune system. Orthologous to human ADAMTS8 (ADAM metallopeptidase with thrombospondin type 1 motif 8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adamts8a Human Ortholog

No data available

Associated With adamts8a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001590	Peptidase M12B, ADAM/reprolysin
Domain	IPR002870	Peptidase M12B, propeptide
Domain	IPR010294	ADAMTS/ADAMTS-like, Spacer 1
Domain	IPR041645	ADAMTS, cysteine-rich domain 2
Domain	IPR045371	ADAMTS/ADAMTS-like, cysteine-rich domain 3
Family	IPR013273	ADAMTS/ADAMTS-like
Family	IPR013277	Peptidase M12B, ADAM-TS8
Homologous_superfamily	IPR024079	Metallopeptidase, catalytic domain superfamily
Homologous_superfamily	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily
Repeat	IPR000884	Thrombospondin type-1 (TSP1) repeat

Domain Details Per Protein

Protein	Length	ADAMTS/ADAMTS-like	ADAMTS/ADAMTS-like, cysteine-rich domain 3	ADAMTS/ADAMTS-like, Spacer 1	ADAMTS, cysteine-rich domain 2	Metallopeptidase, catalytic domain superfamily	Peptidase M12B, ADAM/reprolysin	Peptidase M12B, ADAM-TS8	Peptidase M12B, propeptide	Thrombospondin type-1 (TSP1) repeat	Thrombospondin type-1 (TSP1) repeat superfamily
UniProtKB:A0A8M9QEM5 InterPro	940

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	adamts8a-201 (1) Ensembl	Havana	2653 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations