Gene

dapk1

ID

ZDB-GENE-060526-177

Name

death-associated protein kinase 1

Symbol

dapk1 Nomenclature History

Previous Names

si:ch211-66i11.1
wu:fj09c03

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and positive regulation of apoptotic process. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in urinary bladder cancer. Orthologous to human DAPK1 (death associated protein kinase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Zhou et al., 2020

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dapk1 Human Ortholog

No data available

Associated With dapk1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000488	Death domain
Domain	IPR000719	Protein kinase domain
Domain	IPR020676	Death-associated protein kinase 1, catalytic domain
Domain	IPR020859	Roc domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR011029	Death-like domain superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Length	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	Death-associated protein kinase 1, catalytic domain	Death domain	Death-like domain superfamily	P-loop containing nucleoside triphosphate hydrolase	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Roc domain	Serine/threonine-protein kinase, active site
UniProtKB:A5WVL9 InterPro	1439

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dapk1-201 (1) Ensembl	Havana	6320 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	dapk1-203 (1) Ensembl	Ensembl	6149 nt	Select Tool ZFIN BLAST
mRNA	dapk1-204 (1) Ensembl	Ensembl	6260 nt	Select Tool ZFIN BLAST
ncRNA	dapk1-002 (1) Ensembl	Havana	697 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations