ZFIN ID: ZDB-GENE-060526-131
Gene Name: RUN and SH3 domain containing 2
Gene Symbol: rusc2    Nomenclature History

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Previous Name: si:ch211-250o15.2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Human ortholog(s) of this gene implicated in autosomal recessive mental retardation 61. Is expressed in central nervous system. Orthologous to human RUSC2 (RUN and SH3 domain containing 2).
Genome Resources: Alliance (1),  Gene:556081 (1),  Ensembl(GRCz11):ENSDARG00000095288 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (4 images) from Thisse et al., 2004 [IMAGE:7156060]
Wild-type Stages, Structures: Pharyngula:Prim-15 (30.0h-36.0h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb76 Indel Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • ihb77 Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • ihb78 Insertion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • sa419 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-rusc2 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH rusc2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive mental retardation 61 Alliance Mental retardation, autosomal recessive 61 617773
    DISEASE ASSOCIATED WITH rusc2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component cytoplasmic vesicle (more)
    GO Terms (all 1)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001452 SH3 domain
    Domain IPR004012 RUN domain
    Homologous_superfamily IPR036028 SH3-like domain superfamily
    Homologous_superfamily IPR037213 RUN domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA rusc2-201 (1)    Ensembl 3257
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rusc2 No data available
    MARKER RELATIONSHIPS
    rusc2 Contained in: [BAC] CH211-250O15 (1)
    rusc2 Encodes: [EST] IMAGE:7156060 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_005165190 (1)
    Genomic GenBank:BX510917 (1) 140129 bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8Q7J5 (1) 920 aa
    Sequence Information (all 19)
    ORTHOLOGY for rusc2 ( Chr: 5 )
    CITATIONS (20)