| ZFIN ID: ZDB-GENE-060526-109 |
| Gene Name: | tet methylcytosine dioxygenase 3 | |||||||||||||
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| Gene Symbol: | tet3 Nomenclature History |
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Attributions
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| Previous Name: | si:ch211-220a11.1 (1) | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 5 Mapping Details/Browsers | |||||||||||||
| Description: | Exhibits methylcytosine dioxygenase activity. Involved in several processes, including cell surface receptor signaling pathway; cellular response to lipopolysaccharide; and endothelial to hematopoietic transition. Predicted to localize to nucleus. Is expressed in several structures, including cardiovascular system; eye; hematopoietic system; liver; and pleuroperitoneal region. Orthologous to human TET3 (tet methylcytosine dioxygenase 3). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:103283056 (1), Ensembl(GRCz11):ENSDARG00000062646 (2) | |||||||||||||
| All Expression Data: | 9 figures from 7 publications |
| Wild-type Stages, Structures: | Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult) |
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MUTATIONS AND SEQUENCE TARGETING REAGENTS
| Allele | Type | Localization | Consequence | Mutagen | Suppliers |
|---|---|---|---|---|---|
| au60 | Indel | Exon 6 | Frameshift, Premature Stop | TALEN | |
| ihb2020 | Insertion | Exon 2 | Unknown | TALEN | |
| mk18 | Small Deletion | Unknown | Frameshift, Premature Stop | TALEN | |
| sa9686 | Point Mutation | Unknown | Splice Site | ENU |
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| sa16660 | Point Mutation | Unknown | Premature Stop | ENU |
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| sa33552 | Point Mutation | Unknown | Premature Stop | ENU |
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Sequence Targeting Reagents
| Targeting Reagent | Created Alleles | Publications |
|---|---|---|
| CRISPR1-tet3 |
|
2 |
| CRISPR2-tet3 |
|
2 |
| CRISPR3-tet3 |
|
2 |
| CRISPR4-tet3 |
|
2 |
| CRISPR5-tet3 |
|
2 |
| CRISPR6-tet3 |
|
2 |
| CRISPR7-tet3 |
|
2 |
| CRISPR8-tet3 |
|
2 |
| CRISPR9-tet3 |
|
2 |
| MO1-tet3 | N/A | 1 |
| MO2-tet3 | N/A | 1 |
| TALEN1-tet3 | 1 | |
| TALEN2-tet3 | 1 | |
| TALEN3-tet3 | 1 |
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Beck-Fahrner syndrome | 618798 |
GENE ONTOLOGY
| Ontology | GO Term |
|---|---|
| Biological Process | cell morphogenesis involved in differentiation (more) |
| Cellular Component | nucleus (more) |
| Molecular Function | methylcytosine dioxygenase activity (more) |
| Type | Name | Length (nt) | Analysis | |
|---|---|---|---|---|
| mRNA |
tet3-201
(1)
|
3497 |
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| Browsers: UCSC, NCBI, Ensembl, ZFIN |
INTERACTIONS AND PATHWAYS
ANTIBODIES
No data available
PLASMIDS
No data available
CONSTRUCTS WITH SEQUENCES FROM tet3
No data available
SEQUENCE INFORMATION
| Type | Accession # | Length (nt/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:NM_001082905 (1) |
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|
| Genomic | GenBank:CR388049 (1) | 201176 nt | Blast at MegaBLAST |
| Polypeptide | UniProtKB:A0A2R8Q4R6 (1) | 2052 aa |
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ORTHOLOGY for tet3 (
Chr:
5
)
CITATIONS (36)