ZFIN ID: ZDB-GENE-060522-1
Gene Name: SET and MYND domain containing 1b
Gene Symbol: smyd1b    Nomenclature History

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Previous Names: fla (1), flatline (1), sth

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Exhibits histone methyltransferase activity (H3-K4 specific) and myosin binding activity. Involved in heart contraction; histone H3-K4 methylation; and myofibril assembly. Localizes to the M band. Is expressed in cardiovascular system; musculature system; segmental plate; somite; and tail bud. Orthologous to human SMYD1 (SET and MYND domain containing 1).
Genome Resources: Alliance (1),  Gene:569027 (1),  Ensembl(GRCz11):ENSDARG00000091253 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b212 Unknown Unknown Unknown ENU
sa15678 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34269 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tm123a Insertion Intron 1 Splice Site, Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • to241a Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • zf340 Point Mutation Exon 2 Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-smyd1b
    1
    MO1-smyd1b N/A 4
    MO2-smyd1b N/A 3
    MO3-smyd1b N/A 1
    MO4-smyd1b N/A 2
    MO5-smyd1b N/A 1
    MO6-smyd1b N/A 1
    DISEASE ASSOCIATED WITH smyd1b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH smyd1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process histone H3-K4 methylation (more)
    Cellular Component M band (more)
    Molecular Function histone methyltransferase activity (H3-K4 specific) (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001214 SET domain
    Domain IPR002893 Zinc finger, MYND-type
    Homologous_superfamily IPR011990 Tetratricopeptide-like helical domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA smyd1b-202 (1)    Ensembl 1819
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM smyd1b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(eef1a1l1:smyd1b-GFP) eef1a1l1 GFPsmyd1b Danio rerio 1 3
    Tg(smyd1b:Cca.M3-ck) smyd1b Cyprinus carpioDanio rerio 1 2
    Tg(smyd1b:GFP) smyd1b GFP Danio rerio 1 3
    Tg(unc45b:smyd1b-EGFP) unc45b EGFPsmyd1b Danio rerio 1 2
    Tg1(smyd1b:smyd1b-MYC) smyd1b smyd1b Danio rerio 1 4
    Tg2(smyd1b:smyd1b-MYC) smyd1b smyd1b Danio rerio 1 4
    MARKER RELATIONSHIPS
    smyd1b Contained in: [BAC] CH73-368O6 (1), CH211-14C17 (1)
    [Fosmid] ZFOS-335G10 (1)
    smyd1b Encodes: [cDNA] MGC:194837 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001039636 (1) 1461 bp
    Genomic GenBank:CT027631 (1) 194262 bp
    Select Tool
    Polypeptide UniProtKB:Q2MJQ9 (1) 486 aa
    Sequence Information (all 22)
    ORTHOLOGY for smyd1b ( Chr: 8 )
    CITATIONS (43)