Community Action Needed: Please respond to the NIH RFI
Gene

map2k4a

ID
ZDB-GENE-060512-98
Name
mitogen-activated protein kinase kinase 4a
Symbol
map2k4a Nomenclature History
Previous Names
  • map2k4
  • mkk4a (1)
  • zgc:136500
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to enable JUN kinase kinase activity. Involved in JNK cascade. Acts upstream of or within determination of dorsal identity. Human ortholog(s) of this gene implicated in ovarian serous carcinoma; pancreatic cancer; and urinary bladder cancer. Orthologous to human MAP2K4 (mitogen-activated protein kinase kinase 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Seo et al., 2010
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Rui et al., 2007
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With map2k4a Human Ortholog
No data available
Associated With map2k4a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:B1NA68 404
UniProtKB:D6RRB5 404
UniProtKB:A4FVH5 401
UniProtKB:F1RDF6 378
UniProtKB:Q568X2 236
UniProtKB:E7F090 228
UniProtKB:Q1JPX6 281
UniProtKB:Q9DGR7 281
UniProtKB:X1WFH7 180
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations