| ZFIN ID: ZDB-GENE-060512-241 |
| Gene Name: | forkhead box L2a | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene Symbol: | foxl2a Nomenclature History |
{{control.fieldName}} Edit
Attributions
|
||||||||||||
| Previous Names: | foxl2, zgc:136549 | |||||||||||||
Add new Alias
Attributions for Alias: {{control.newAlias}}
Delete Alias:(Including Attributions) |
||||||||||||||
| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 15 Mapping Details/Browsers | |||||||||||||
| Description: | Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in maintenance of animal organ identity. Predicted to localize to nucleus. Is expressed in female organism; gonad; ovarian follicle; ovary; and testis. Human ortholog(s) of this gene implicated in blepharophimosis, ptosis, and epicanthus inversus syndrome and premature ovarian failure. Orthologous to human FOXL2 (forkhead box L2). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:692279 (1), Ensembl(GRCz11):ENSDARG00000042180 (1) | |||||||||||||
| All Expression Data: | 9 figures from 8 publications |
| Wild-type Stages, Structures: | Larval:Days 14-20 (14d-21d, 6.2mm, 10 teeth) to Adult (90d-730d, breeding adult) |
MUTATIONS AND SEQUENCE TARGETING REAGENTS
| Allele | Type | Localization | Consequence | Mutagen | Suppliers |
|---|---|---|---|---|---|
| el615 | Indel | Unknown | Unknown | CRISPR | |
| ihb172 | Small Deletion | Unknown | Frameshift | TALEN |
Sequence Targeting Reagents
| Targeting Reagent | Created Alleles | Publications |
|---|---|---|
| CRISPR1-foxl2a | 1 | |
| TALEN1-foxl2a | 1 | |
| TALEN1-foxl2b | 1 |
PHENOTYPE
| Data: | 5 figures from Yang et al., 2017 |
| Observed in: |
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| blepharophimosis, ptosis, and epicanthus inversus syndrome | Alliance | Blepharophimosis, epicanthus inversus, and ptosis, type 1 | 110100 |
| Blepharophimosis, epicanthus inversus, and ptosis, type 2 | 110100 | ||
| premature ovarian failure | Alliance | Premature ovarian failure 3 | 608996 |
GENE ONTOLOGY
| Ontology | GO Term |
|---|---|
| Biological Process | maintenance of animal organ identity (more) |
| Cellular Component | nucleus (more) |
| Molecular Function | DNA binding (more) |
| Type | Name | Length (nt) | Analysis | |
|---|---|---|---|---|
| mRNA |
foxl2a-201
(1)
|
1057 |
Select Tool
|
|
|
foxl2a-202
(1)
|
403 |
Select Tool
|
| Browsers: UCSC, NCBI, Ensembl, ZFIN |
INTERACTIONS AND PATHWAYS
ANTIBODIES
No data available
PLASMIDS
No data available
CONSTRUCTS WITH SEQUENCES FROM foxl2a
No data available
MARKER RELATIONSHIPS
| foxl2a Contained in: | [BAC] CH73-232G7 (1) |
| foxl2a Encodes: | [cDNA] MGC:136549 (1) |
SEQUENCE INFORMATION
| Type | Accession # | Length (nt/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:NM_001045252 (1) | 1070 nt |
Select Tool
|
| Genomic | GenBank:CU571391 (1) | 52512 nt | |
| Polypeptide | UniProtKB:Q1JPV2 (1) | 306 aa |
Select Tool
|
ORTHOLOGY for foxl2a (
Chr:
15
)
CITATIONS (45)