ZFIN ID: ZDB-GENE-060512-241
Gene Name: forkhead box L2a
Gene Symbol: foxl2a    Nomenclature History

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Previous Names: foxl2, zgc:136549

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in maintenance of animal organ identity. Predicted to localize to nucleus. Is expressed in female organism; gonad; ovarian follicle; ovary; and testis. Human ortholog(s) of this gene implicated in blepharophimosis, ptosis, and epicanthus inversus syndrome and premature ovarian failure. Orthologous to human FOXL2 (forkhead box L2).
Genome Resources: Alliance (1),  Gene:692279 (1),  Ensembl(GRCz11):ENSDARG00000042180 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
el615 Indel Unknown Unknown CRISPR
ihb172 Small Deletion Unknown Frameshift TALEN
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-foxl2a 1
TALEN1-foxl2a 1
TALEN1-foxl2b 1
DISEASE ASSOCIATED WITH foxl2a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
blepharophimosis, ptosis, and epicanthus inversus syndrome Alliance Blepharophimosis, epicanthus inversus, and ptosis, type 1 110100
Blepharophimosis, epicanthus inversus, and ptosis, type 2 110100
premature ovarian failure Alliance Premature ovarian failure 3 608996
DISEASE ASSOCIATED WITH foxl2a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process maintenance of animal organ identity (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA foxl2a-201 (1)    Ensembl 1057
foxl2a-202 (1)    Ensembl 403
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM foxl2a No data available
MARKER RELATIONSHIPS
foxl2a Contained in: [BAC] CH73-232G7 (1)
foxl2a Encodes: [cDNA] MGC:136549 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001045252 (1) 1070 nt
Genomic GenBank:CU571391 (1) 52512 nt
Select Tool
Polypeptide UniProtKB:Q1JPV2 (1) 306 aa
Sequence Information (all 15)
ORTHOLOGY for foxl2a ( Chr: 15 )
CITATIONS (45)