ZFIN ID: ZDB-GENE-060503-925
Gene Name: carnitine palmitoyltransferase 1Aa (liver)
Gene Symbol: cpt1aa    Nomenclature History

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Previous Names: cpt1a, si:dkey-56p7.8

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have carnitine O-palmitoyltransferase activity. Involved in lymphangiogenesis and regulation of fatty acid beta-oxidation. Predicted to localize to mitochondrion. Is expressed in liver and male organism. Human ortholog(s) of this gene implicated in carnitine palmitoyltransferase I deficiency and lipid metabolism disorder. Orthologous to human CPT1A (carnitine palmitoyltransferase 1A).
Genome Resources: Alliance (1),  Gene:558088 (1),  Ensembl(GRCz11):ENSDARG00000059770 (2)
GENE EXPRESSION
All Expression Data: 8 figures from 8 publications
Wild-type Stages, Structures: Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa16862 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34169 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cpt1aa N/A 1
    MO2-cpt1aa N/A 1
    DISEASE ASSOCIATED WITH cpt1aa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    carnitine palmitoyltransferase I deficiency Alliance CPT deficiency, hepatic, type IA 255120
    DISEASE ASSOCIATED WITH cpt1aa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process fatty acid beta-oxidation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function carnitine O-palmitoyltransferase activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cpt1aa-201 (1)    Ensembl 2325
    cpt1aa-202 (1)    Ensembl 3354
    cpt1aa-203 (1)    Ensembl 440
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cpt1aa No data available
    MARKER RELATIONSHIPS
    cpt1aa Contained in: [BAC] DKEY-56P7 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001044854 (1) 2476 nt
    Genomic GenBank:AL929208 (1) 189608 nt
    Select Tool
    Polypeptide UniProtKB:A0A1L1U0X8 (1) 774 aa
    Sequence Information (all 14)
    ORTHOLOGY for cpt1aa ( Chr: 7 )
    CITATIONS (65)