ZFIN ID: ZDB-GENE-060503-867
Gene Name: heat shock protein family A (Hsp70) member 1B
Gene Symbol: hspa1b    Nomenclature History

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Previous Name: si:ch211-199o1.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have several functions, including ATP binding activity; misfolded protein binding activity; and protein folding chaperone. Predicted to be involved in several processes, including cellular response to unfolded protein; chaperone cofactor-dependent protein refolding; and protein refolding. Predicted to colocalize with COP9 signalosome. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease of musculoskeletal system (multiple); cystic fibrosis; schizophrenia (multiple); and vascular dementia. Orthologous to several human genes including HSPA1L (heat shock protein family A (Hsp70) member 1 like).
Genome Resources: Alliance (1),  Gene:798846 (1),  Ensembl(GRCz11):ENSDARG00000056210 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa41204 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH hspa1b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH hspa1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to unfolded protein (more)
    Cellular Component COLOCALIZES_WITH   COP9 signalosome (more)
    Molecular Function ATP binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA si:ch211-199o1.2-201 (1)    Ensembl 2020
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hspa1b No data available
    MARKER RELATIONSHIPS
    hspa1b Contained in: [BAC] CH211-199O1 (1), RP71-15H20 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001100062 (1) 2020 nt
    Genomic GenBank:AL773601 201299 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A5PMG2 (1) 639 aa
    Sequence Information (all 8)
    ORTHOLOGY for hspa1b ( Chr: 8 )
    CITATIONS (16)