ZFIN ID: ZDB-GENE-060503-864
Gene Name: EYA transcriptional coactivator and phosphatase 3
Gene Symbol: eya3    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: si:ch211-195b13.2, zgc:152966

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have protein tyrosine phosphatase activity. Predicted to be involved in several processes, including histone dephosphorylation; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; and positive regulation of DNA repair. Predicted to localize to the nucleus. Is expressed in brain; head; immature eye; and olfactory placode. Orthologous to human EYA3 (EYA transcriptional coactivator and phosphatase 3).
Genome Resources: Alliance (1),  Gene:571385 (1),  Ensembl(GRCz11):ENSDARG00000036100 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa29209 Point Mutation Unknown Splice Site ENU
PHENOTYPE No data available
DISEASE ASSOCIATED WITH eya3 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH eya3 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process multicellular organism development (more)
Cellular Component transcription factor complex (more)
Molecular Function hydrolase activity (more)
GO Terms (all 12)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR006545 EYA domain
Family IPR028472 Eyes absent family
Family IPR028479 Eyes absent homologue 3
Homologous_superfamily IPR038102 EYA domain superfamily
Domain IPR042577 EYA domain, metazoan
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA eya3-202 (1)    Ensembl 3304
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM eya3 No data available
MARKER RELATIONSHIPS
eya3 Contained in: [BAC] CH211-195B13 (1)
eya3 Encodes: [EST] fa02d09 (1)
[cDNA] MGC:152966 (1), MGC:192975 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001080052 (1) 3297 bp
Genomic GenBank:BX530721 (1) 201156 bp Blast at MegaBLAST
Polypeptide UniProtKB:A3KQ54 (1) 617 aa
Sequence Information (all 25)
ORTHOLOGY for eya3 ( Chr: 19 )
CITATIONS (24)