Gene

cdk6

ID
ZDB-GENE-060503-786
Name
cyclin-dependent kinase 6
Symbol
cdk6 Nomenclature History
Previous Names
  • si:ch211-234f14.1
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to have RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and regulation of cell cycle. Predicted to localize to mediator complex. Is expressed in brain; gill; gonad; kidney; and retina. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; malignant glioma; pancreatic adenocarcinoma; pancreatic ductal carcinoma; and primary autosomal recessive microcephaly 12. Orthologous to human CDK6 (cyclin dependent kinase 6).
Genome Resources
Note
None
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Webster et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cdk6 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
primary autosomal recessive microcephaly 12 Alliance ?Microcephaly 12, primary, autosomal recessive 616080
Associated With cdk6 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Family IPR028788 Cyclin-dependent kinase 6
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Cyclin-dependent kinase 6 Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:E9QFH2 302
UniProtKB:I3IT74 324
UniProtKB:F6NR87 68
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations