Gene

egln2

ID
ZDB-GENE-060503-757
Name
egl-9 family hypoxia-inducible factor 2
Symbol
egln2 Nomenclature History
Previous Names
  • Hif-p4H-1 (1)
  • si:ch211-113p18.4
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have ferrous iron binding activity and peptidyl-proline 4-dioxygenase activity. Predicted to be involved in cellular response to hypoxia and peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human EGLN2 (egl-9 family hypoxia inducible factor 2).
Genome Resources
Note
None
Expression
All Expression Data
Fig. 3 from Hyvarinen et al., 2010
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With egln2 Human Ortholog
No data available
Associated With egln2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR005123 Oxoglutarate/iron-dependent dioxygenase
Domain IPR006620 Prolyl 4-hydroxylase, alpha subunit
Domain Details Per Protein
Protein Length Oxoglutarate/iron-dependent dioxygenase Prolyl 4-hydroxylase, alpha subunit
UniProtKB:E7F8S1 464
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations