ZFIN ID: ZDB-GENE-060503-743
Gene Name: dedicator of cytokinesis 8
Gene Symbol: dock8    Nomenclature History

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Previous Names: im:7154406 (1), si:dkey-91m11.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have guanyl-nucleotide exchange factor activity. Predicted to be involved in small GTPase mediated signal transduction. Is expressed in forebrain; midbrain; and ventricular zone. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 2 and hyper IgE recurrent infection syndrome 2. Orthologous to human DOCK8 (dedicator of cytokinesis 8).
Genome Resources: Alliance (1),  Gene:403040 (1),  Ensembl(GRCz11):ENSDARG00000055225 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (2 images) from Thisse et al., 2004 [IMAGE:7154406]
Wild-type Stages, Structures: Pharyngula:High-pec (42.0h-48.0h) to Hatching:Long-pec (48.0h-60.0h)
 
PHENOTYPE No data available
DISEASE ASSOCIATED WITH dock8 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hyper IgE recurrent infection syndrome 2 Alliance Hyper-IgE recurrent infection syndrome, autosomal recessive 243700
DISEASE ASSOCIATED WITH dock8 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process small GTPase mediated signal transduction (more)
Molecular Function guanyl-nucleotide exchange factor activity (more)
GO Terms (all 2)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA dock8-202 (1)    Ensembl 910
dock8-203 (1)    Ensembl 7072
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM dock8 No data available
MARKER RELATIONSHIPS
dock8 Contained in: [BAC] CH211-100P3 (1), DKEY-91M11 (1) (order this)
dock8 Encodes: [EST] IMAGE:7154406 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_001920072 (1) 7574 nt
Genomic GenBank:AL845168 (1) 198627 nt
Select Tool
Polypeptide UniProtKB:F1QJ79 (1) 2090 aa
Sequence Information (all 22)
ORTHOLOGY for dock8 ( Chr: 8 )
CITATIONS (18)