ZFIN ID: ZDB-GENE-060503-723
Gene Name: coiled-coil domain containing 40
Gene Symbol: ccdc40    Nomenclature History

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Previous Names: im:7149866, lok, si:dkey-237i9.5, wu:fb11d02

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Involved in axoneme assembly; determination of left/right symmetry; and pronephros development. Predicted to localize to cilium and cytoplasm. Is expressed in several structures, including Kupffer's vesicle; forerunner cell group; nervous system; pronephric duct; and pronephric mesoderm. Used to study primary ciliary dyskinesia. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 15. Orthologous to human CCDC40 (coiled-coil domain containing 40).
Genome Resources: Alliance (1),  Gene:568590 (1),  Ensembl(GRCz11):ENSDARG00000100584 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la029191Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m505 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa8996 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13373 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tj8 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tl215 Unknown Unknown Unknown ENU
    tm138a Unknown Unknown Unknown ENU
    to237b Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ts277 Unknown Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ccdc40 N/A 1
    MO2-ccdc40 N/A 1
    DISEASE ASSOCIATED WITH ccdc40 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    primary ciliary dyskinesia 15 Alliance Ciliary dyskinesia, primary, 15 613808
    DISEASE ASSOCIATED WITH ccdc40 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    primary ciliary dyskinesia ccdc40to237b/to237b standard conditions Song et al., 2016
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axoneme assembly (more)
    Cellular Component cilium (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ccdc40-202 (1)    Ensembl 3370
    ncRNA ottdart00000054945 (1)    Ensembl 583
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ccdc40 No data available
    MARKER RELATIONSHIPS
    ccdc40 Contained in: [BAC] DKEY-31G6 (1) (order this), DKEY-210O7 (order this), DKEY-237I9 (1) (order this)
    ccdc40 Encodes: [EST] fb11d02, IMAGE:7149866 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001271813 (1)
    Genomic GenBank:BX571728 229059 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8PW94 (1) 941 aa
    Sequence Information (all 19)
    ORTHOLOGY for ccdc40 ( Chr: 6 )
    CITATIONS (44)