Gene

irak3

ID
ZDB-GENE-060503-710
Name
interleukin-1 receptor-associated kinase 3
Symbol
irak3 Nomenclature History
Previous Names
  • si:dkey-150i15.2
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within embryonic hemopoiesis. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IRAK3 (interleukin 1 receptor associated kinase 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from Stockhammer et al., 2009
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Eckfeldt et al., 2005
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With irak3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Asthma susceptibility 5} 611064
Associated With irak3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000488 Death domain
Domain IPR000719 Protein kinase domain
Domain IPR042698 Interleukin-1 receptor-associated kinase 3, pseudokinase domain
Domain IPR042747 IRAK3, death domain
Family IPR033610 Interleukin-1 receptor-associated kinase 3
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR011029 Death-like domain superfamily
Domain Details Per Protein
Protein Length Death domain Death-like domain superfamily Interleukin-1 receptor-associated kinase 3 Interleukin-1 receptor-associated kinase 3, pseudokinase domain IRAK3, death domain Protein kinase domain Protein kinase-like domain superfamily
UniProtKB:A0A2R8QAK9 374
UniProtKB:A0A2R8QTA8 332
UniProtKB:Q4KMD6 621
UniProtKB:B0UYS2 630
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations