Gene

slc26a4

ID

ZDB-GENE-060503-544

Name

solute carrier family 26 member 4

Symbol

slc26a4 Nomenclature History

Previous Names

si:dkey-31f5.9

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have anion transmembrane transporter activity. Involved in anion homeostasis; chloride transport; and response to salt stress. Predicted to localize to integral component of plasma membrane. Human ortholog(s) of this gene implicated in Pendred Syndrome; autosomal recessive nonsyndromic deafness 4; and goiter. Is expressed in several structures, including gill; heart; liver; muscle; and pleuroperitoneal region. Orthologous to human SLC26A4 (solute carrier family 26 member 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With slc26a4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 4	Alliance	Deafness, autosomal recessive 4, with enlarged vestibular aqueduct	600791
Pendred Syndrome	Alliance	Pendred syndrome	274600

Associated With slc26a4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018045	Sulphate anion transporter, conserved site
Domain	IPR002645	STAS domain
Domain	IPR011547	SLC26A/SulP transporter domain
Family	IPR001902	SLC26A/SulP transporter
Homologous_superfamily	IPR036513	STAS domain superfamily