ZFIN ID: ZDB-GENE-060503-526
Gene Name: vacuolar protein sorting 45 homolog
Gene Symbol: vps45    Nomenclature History

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Previous Name: si:dkey-200h23.3

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Involved in regulation of lens fiber cell differentiation. Human ortholog(s) of this gene implicated in severe congenital neutropenia. Orthologous to human VPS45 (vacuolar protein sorting 45 homolog).
Genome Resources: Alliance (1),  Gene:561653 (1),  Ensembl(GRCz11):ENSDARG00000061180 (2)
GENE EXPRESSION
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
rw341 Insertion Unknown Unknown ENU
sa14216 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45682 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-vps45 N/A 1
    MO2-vps45 N/A 1
    DISEASE ASSOCIATED WITH vps45 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Neutropenia, severe congenital, 5, autosomal recessive 615285
    DISEASE ASSOCIATED WITH vps45 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of lens fiber cell differentiation (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR001619 Sec1-like protein
    Homologous_superfamily IPR027482 Sec1-like, domain 2
    Homologous_superfamily IPR036045 Sec1-like superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA vps45-201 (1)    Ensembl 2518
    ncRNA vps45-002 (1)    Ensembl 645
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM vps45
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(cryaa:vps45-gfp) cryaa GFPvps45 Danio rerio 1 1
    tg(foxe3:vps45-gfp) foxe3 GFPvps45 Danio rerio 1 1
    MARKER RELATIONSHIPS
    vps45 Contained in: [BAC] DKEY-200H23 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001256656 (1)
    Genomic GenBank:BX571688 (1) 181466 bp
    Select Tool
    Polypeptide UniProtKB:A8E7N5 (1) 568 aa
    Sequence Information (all 5)
    ORTHOLOGY for vps45 ( Chr: 19 )
    CITATIONS (17)