Gene

dyrk1b

ID
ZDB-GENE-060503-499
Name
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
Symbol
dyrk1b Nomenclature History
Previous Names
  • si:ch211-225p5.1
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Is predicted to enable protein serine/threonine kinase activity and transcription coactivator activity. Involved in peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; and positive regulation of transcription, DNA-templated. Acts upstream of or within endoderm formation. Is expressed in head and somite. Human ortholog(s) of this gene implicated in abdominal obesity-metabolic syndrome 3. Orthologous to human DYRK1B (dual specificity tyrosine phosphorylation regulated kinase 1B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Mazmanian et al., 2010
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Mazmanian et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dyrk1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
abdominal obesity-metabolic syndrome 3 Alliance Abdominal obesity-metabolic syndrome 3 615812
Associated With dyrk1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR044131 Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain
Family IPR028318 Dual specificity tyrosine-phosphorylation-regulated kinase 1A/B
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain Dual specificity tyrosine-phosphorylation-regulated kinase 1A/B Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:A0A0R4II39 681
UniProtKB:D1L3Y5 751
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations