ZFIN ID: ZDB-GENE-060503-499
Gene Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
Gene Symbol: dyrk1b    Nomenclature History

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Previous Name: si:ch211-225p5.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity and transcription coactivator activity. Involved in endoderm formation. Predicted to localize to nucleus. Is expressed in head and somite. Human ortholog(s) of this gene implicated in abdominal obesity-metabolic syndrome 3. Orthologous to human DYRK1B (dual specificity tyrosine phosphorylation regulated kinase 1B).
Genome Resources: Alliance (1),  Gene:556212 (1),  Ensembl(GRCz11):ENSDARG00000070187 (2)
GENE EXPRESSION
All Expression Data: 2 figures from Mazmanian et al., 2010
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa44858 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dyrk1b N/A 2
    MO2-dyrk1b N/A 2
    DISEASE ASSOCIATED WITH dyrk1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    abdominal obesity-metabolic syndrome 3 Alliance Abdominal obesity-metabolic syndrome 3 615812
    DISEASE ASSOCIATED WITH dyrk1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process endoderm formation (more)
    Cellular Component nucleus (more)
    Molecular Function ATP binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dyrk1b-201 (1)    Ensembl 4382
    ncRNA dyrk1b-002 (1) 918
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dyrk1b No data available
    MARKER RELATIONSHIPS
    dyrk1b Contained in: [BAC] CH211-225P5 (1), DKEY-255N6 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001168265 (1)
    Genomic GenBank:BX649388 (1) 177865 nt
    Select Tool
    Polypeptide UniProtKB:D1L3Y5 (1) 751 aa
    Sequence Information (all 18)
    ORTHOLOGY for dyrk1b ( Chr: 16 )
    CITATIONS (20)