ZFIN ID: ZDB-GENE-060503-491
Gene Name: calpain 1, (mu/I) large subunit b
Gene Symbol: capn1b    Nomenclature History

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Previous Names: si:ch211-203k12.4, si:dkeyp-101g1.3

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity and calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to localize to cytoplasm. Is expressed in brain; embryonic structure; myotome; and neurons. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 76. Orthologous to several human genes including CAPN11 (calpain 11).
Genome Resources: Alliance (1),  Gene:565106 (1),  Ensembl(GRCz11):ENSDARG00000052748 (1)
GENE EXPRESSION
All Expression Data: 7 figures from 3 publications
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Hatching:Long-pec (48.0h-60.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa43861 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43862 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-capn1b N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH capn1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hereditary spastic paraplegia 76 Alliance Spastic paraplegia 76, autosomal recessive 616907
    DISEASE ASSOCIATED WITH capn1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process proteolysis (more)
    Cellular Component cytoplasm (more)
    Molecular Function calcium-dependent cysteine-type endopeptidase activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA capn1b-201 (1)    Ensembl 2103
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM capn1b No data available
    MARKER RELATIONSHIPS
    capn1b Contained in: [BAC] CH211-203K12 (1), DKEYP-101G1 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001144795 (1) 2103 nt
    Genomic GenBank:BX004801 113290 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IG81 (1) 700 aa
    Sequence Information (all 9)
    ORTHOLOGY for capn1b ( Chr: 22 )
    CITATIONS (21)