ZFIN ID: ZDB-GENE-060503-382
Gene Name: thyrotropin-releasing hormone receptor b
Gene Symbol: trhrb    Nomenclature History

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Previous Names: trhr1, trhr, si:ch211-122p23.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have thyrotropin-releasing hormone receptor activity. Predicted to be involved in phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene implicated in congenital hypothyroidism and hypertension. Orthologous to human TRHR (thyrotropin releasing hormone receptor).
Genome Resources: Alliance (1),  Gene:569382 (1),  Ensembl(GRCz11):ENSDARG00000036159 (1)
GENE EXPRESSION
All Expression Data: Fig. 7 from Liu et al., 2016
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12805 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23513 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH trhrb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Hypothyroidism, congenital, nongoitrous, 7 618573
    DISEASE ASSOCIATED WITH trhrb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process G protein-coupled receptor signaling pathway (more)
    Cellular Component integral component of membrane (more)
    Molecular Function G protein-coupled receptor activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000276 G protein-coupled receptor, rhodopsin-like
    Family IPR002120 Thyrotropin-releasing hormone receptor
    Domain IPR017452 GPCR, rhodopsin-like, 7TM
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA trhrb-201 (1)    Ensembl 2112
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM trhrb No data available
    MARKER RELATIONSHIPS
    trhrb Contained in: [BAC] CH211-122P23 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001114688 (1) 1200 bp
    Genomic GenBank:BX511206 (1) 165585 bp
    Select Tool
    Polypeptide UniProtKB:A8E7L5 (1) 399 aa
    Sequence Information (all 5)
    ORTHOLOGY for trhrb ( Chr: 19 )
    CITATIONS (27)