Gene

trhrb

ID

ZDB-GENE-060503-382

Name

thyrotropin-releasing hormone receptor b

Symbol

trhrb Nomenclature History

Previous Names

trhr1
trhr
si:ch211-122p23.1

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have thyrotropin-releasing hormone receptor activity. Predicted to be involved in phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in congenital hypothyroidism and hypertension. Orthologous to human TRHR (thyrotropin releasing hormone receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With trhrb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital nongoitrous hypothyroidism 7	Alliance	Hypothyroidism, congenital, nongoitrous, 7	618573

Associated With trhrb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR017452	GPCR, rhodopsin-like, 7TM
Family	IPR000276	G protein-coupled receptor, rhodopsin-like
Family	IPR002120	Thyrotropin-releasing hormone receptor