ZFIN ID: ZDB-GENE-060503-376
Gene Name: lysine (K)-specific methyltransferase 2Ba
Gene Symbol: kmt2ba    Nomenclature History

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Previous Names: mll4a, si:rp71-15k1.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have histone methyltransferase activity (H3-K4 specific). Predicted to be involved in histone H3-K4 methylation and positive regulation of transcription, DNA-templated. Predicted to localize to histone methyltransferase complex. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; dystonia; and hepatocellular carcinoma. Orthologous to human KMT2B (lysine methyltransferase 2B).
Genome Resources: Alliance (1),  Gene:560856 (1),  Ensembl(GRCz11):ENSDARG00000062962 (2)
GENE EXPRESSION
All Expression Data: Fig. S6 from Sun et al., 2008
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Blastula:Sphere (4.0h-4.33h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH kmt2ba HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Dystonia 28, childhood-onset 617284
DISEASE ASSOCIATED WITH kmt2ba VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process chromatin organization (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 12)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
antisense ottdart00000059906 (1) 684
mRNA kmt2ba-201 (1)    Ensembl 9950
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM kmt2ba No data available
MARKER RELATIONSHIPS
kmt2ba Contained in: [BAC] CH211-130O18 (1), RP71-15K1 (1)
kmt2ba Encodes: [EST] wz12125 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_684255 (1) 10149 nt
Genomic GenBank:CR391915 (1) 77634 nt
Select Tool
Polypeptide UniProtKB:A0A2R8Q4Z6 (1) 2945 aa
Sequence Information (all 31)
ORTHOLOGY for kmt2ba ( Chr: 19 )
CITATIONS (27)