ZFIN Gene: pax1b

ZFIN ID: ZDB-GENE-060503-372

ZFIN ID: ZDB-GENE-060503-372

Gene Name:

paired box 1b

Gene Symbol:

pax1b Nomenclature History

Previous Name:

si:dkeyp-50f5.1

Gene Type:

protein_coding_gene

Location:

Chr: 20 Mapping Details/Browsers

Description:

Predicted to have DNA binding activity and DNA-binding transcription factor activity. Involved in embryonic skeletal system development and pectoral fin development. Predicted to localize to nucleus. Is expressed in axial blood vessel; fin bud; notochord; pharynx; and somite. Human ortholog(s) of this gene implicated in branchiootorenal syndrome. Orthologous to human PAX1 (paired box 1).

Genome Resources:

Alliance (1), Gene:572108 (1), Ensembl(GRCz11):ENSDARG00000073814 (1)

GENE EXPRESSION
All Expression Data:	Fig. 3 from Liu et al., 2013
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Hatching:Long-pec (48.0h-60.0h)
	dorsal aorta fin bud notochord pharyngeal endoderm pharyngeal pouch posterior cardinal vein somite unspecified whole organism
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa43535	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-pax1b	N/A	2
MO2-pax1b	N/A	1

PHENOTYPE

Data:	4 figures from 2 publications
Observed in:	fin bud pectoral fin pectoral fin bud pectoral fin development post-vent region splanchnocranium whole organism anterior-posterior axis whole organism

DISEASE ASSOCIATED WITH pax1b HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Otofaciocervical syndrome 2	615560

DISEASE ASSOCIATED WITH pax1b VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	embryonic skeletal system development (more)
Cellular Component	nucleus (more)
Molecular Function	protein binding (more)

GO Terms (all 8)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	pax1b-201 (1)	1659	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM pax1b No data available

MARKER RELATIONSHIPS

pax1b Contained in:

[BAC] DKEYP-50F5 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_695785 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Genomic	GenBank:BX663521 (1)	179633 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A2R8PYI0 (1)	353 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 11)

ORTHOLOGY for pax1b ( Chr: 20 )

CITATIONS (21)

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