Gene

pax1b

ID
ZDB-GENE-060503-372
Name
paired box 1b
Symbol
pax1b Nomenclature History
Previous Names
  • si:dkeyp-50f5.1
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in anatomical structure development and regulation of transcription by RNA polymerase II. Acts upstream of or within embryonic skeletal system development and pectoral fin development. Predicted to be located in nucleus. Is expressed in axial blood vessel; fin bud; notochord; pharynx; and somite. Human ortholog(s) of this gene implicated in branchiootorenal syndrome. Orthologous to human PAX1 (paired box 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Liu et al., 2013
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pax1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Otofaciocervical syndrome 2 615560
Associated With pax1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001523 Paired domain
Domain IPR043182 Paired DNA-binding domain
Family IPR033206 Paired box protein PAX1
Family IPR043565 PAX family
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Homeobox-like domain superfamily Paired box protein PAX1 Paired DNA-binding domain Paired domain PAX family Winged helix-like DNA-binding domain superfamily
UniProtKB:A0A2R8Q5G5 337
UniProtKB:A0A2R8PYI0 353
UniProtKB:B0S7C8 340
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations