ZFIN ID: ZDB-GENE-060503-334
Gene Name: trio Rho guanine nucleotide exchange factor a
Gene Symbol: trioa    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: si:ch211-13c6.1, si:dkey-158b13.2

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have ATP binding activity; Rho guanyl-nucleotide exchange factor activity; and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and regulation of Rho protein signal transduction. Predicted to localize to the cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 44. Orthologous to human TRIO (trio Rho guanine nucleotide exchange factor).
Genome Resources: Alliance (1),  Gene:557667 (1),  Ensembl(GRCz11):ENSDARG00000019426 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la020840Tg Transgenic Insertion Unknown Unknown DNA
la020841Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11605 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12039 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12333 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23586 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32258 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36903 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36904 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36905 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36906 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44923 Point Mutation Unknown Unknown ENU
    sa44924 Point Mutation Unknown Unknown ENU
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH trioa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant non-syndromic intellectual disability 44 Alliance Mental retardation, autosomal dominant 44 617061
    DISEASE ASSOCIATED WITH trioa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axon guidance (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000219 Dbl homology (DH) domain
    Domain IPR000719 Protein kinase domain
    Domain IPR001251 CRAL-TRIO lipid binding domain
    Domain IPR001452 SH3 domain
    Domain IPR001849 Pleckstrin homology domain
    Repeat IPR002017 Spectrin repeat
    Domain IPR003598 Immunoglobulin subtype 2
    Domain IPR003599 Immunoglobulin subtype
    Domain IPR007110 Immunoglobulin-like domain
    Active_site IPR008271 Serine/threonine-protein kinase, active site
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    Homologous_superfamily IPR011993 PH-like domain superfamily
    Domain IPR013098 Immunoglobulin I-set
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Binding_site IPR017441 Protein kinase, ATP binding site
    Repeat IPR018159 Spectrin/alpha-actinin
    Family IPR028570 Triple functional domain protein
    Homologous_superfamily IPR035899 Dbl homology (DH) domain superfamily
    Homologous_superfamily IPR036028 SH3-like domain superfamily
    Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
    Homologous_superfamily IPR036865 CRAL-TRIO lipid binding domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA trioa-202 (1)    Ensembl 9945
    ncRNA trioa-002 (1)    Ensembl 614
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM trioa No data available
    MARKER RELATIONSHIPS
    trioa Contained in: [BAC] CH211-13C6 (1), DKEY-158B13 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001104526 (1) 9755 bp
    Genomic GenBank:BX950864 (1) 185429 bp
    Select Tool
    Polypeptide UniProtKB:F1Q551 (1) 3087 aa
    Sequence Information (all 29)
    ORTHOLOGY for trioa ( Chr: 19 )
    CITATIONS (21)