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ZIRC
ZFIN ID: ZDB-GENE-060503-315
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Gene Name: synaptotagmin IIa
Gene Symbol: syt2a    Nomenclature History

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Previous Name: si:ch211-236j4.1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have several functions, including calcium ion binding activity; phospholipid binding activity; and syntaxin binding activity. Predicted to be involved in cellular response to calcium ion; regulation of secretion by cell; and synaptic vesicle cycle. Predicted to localize to the axon; plasma membrane; and secretory vesicle. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 7. Orthologous to human SYT2 (synaptotagmin 2).
Genome Resources: Alliance (1),  Gene:567877 (1),  Ensembl(GRCz11):ENSDARG00000025206 (1)
GENE EXPRESSION
All Expression Data: Fig. 2 from Kiesow et al., 2015
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011005Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • la022794Tg Transgenic Insertion Unknown Unknown DNA
    la022795Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH syt2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital myasthenic syndrome 7 Alliance Myasthenic syndrome, congenital, 7, presynaptic 616040
    DISEASE ASSOCIATED WITH syt2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process neurotransmitter secretion (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium-dependent phospholipid binding (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000008 (1)
  • InterPro:IPR001565 (1)
  • InterPro:IPR015428 (1)
  • InterPro:IPR035892 (1)
  • PROSITE:PS50004 (1)
  • Pfam:PF00168 (1)
    • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA syt2a-202 (1)    Ensembl 1951
    Select Tool
    ncRNA syt2a-002 (1) 659
    Select Tool
    Browsers: NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM syt2a No data available
    MARKER RELATIONSHIPS
    syt2a Contained in: [BAC] CH211-212J22 (1) (order this), CH211-236J4 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_005174112 (1)
    Select Tool
    Genomic GenBank:BX323087 (1) 192603 bp
    Select Tool
    Polypeptide UniProtKB:F1R5C0 (1) 430 aa
    Select Tool
    Sequence Clusters UniGene:120327 (1)
    Sequence Information (all 16)
    ORTHOLOGY for syt2a ( Chr: 23 )
    CITATIONS (24)