Gene

pvrl2l

ID

ZDB-GENE-060503-249

Name

PVR cell adhesion molecule related 2 like

Symbol

pvrl2l Nomenclature History

Previous Names

si:dkey-225e11.1

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have cell adhesion molecule binding activity; protein homodimerization activity; and signaling receptor activity. Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules and homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to localize to adherens junction. Human ortholog(s) of this gene implicated in Alzheimer's disease and multiple sclerosis. Is expressed in cardiovascular system; epidermis; nervous system; and neural plate. Orthologous to human PVR (PVR cell adhesion molecule) and NECTIN2 (nectin cell adhesion molecule 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from Thisse et al., 2008

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cssl:d0618 (25 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pvrl2l Human Ortholog

No data available

Associated With pvrl2l Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013106	Immunoglobulin V-set domain
Domain	IPR013162	CD80-like, immunoglobulin C2-set
Family	IPR052659	Nectin and Poliovirus Receptor
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily