Gene
ubap2l
- ID
- ZDB-GENE-060503-244
- Name
- ubiquitin associated protein 2-like
- Symbol
- ubap2l Nomenclature History
- Previous Names
-
- sb:eu902
- si:dkey-204a24.7
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to be active in cytoplasm and nucleus. Orthologous to human UBAP2L (ubiquitin associated protein 2 like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu902 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa32231 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa36779 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa36780 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa43218 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa43219 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with impaired language, behavioral abnormalities, and dysmorphic facies | 620494 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Transcription-coupled DNA damage response regulator-like | UBA-like superfamily | UBAP2/protein lingerer | Ubiquitin-associated domain |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9P1N2 | InterPro | 1196 | ||||
| UniProtKB:A0A8M2B5X1 | InterPro | 1212 | ||||
| UniProtKB:Q1L8T3 | InterPro | 1144 | ||||
| UniProtKB:A0A8M9PN11 | InterPro | 1197 | ||||
| UniProtKB:A0A8M9PAR6 | InterPro | 1160 | ||||
| UniProtKB:A0A8M9PR82 | InterPro | 1211 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ubap2l-201
(1)
|
Ensembl | 5,187 nt | ||
| mRNA |
ubap2l-202
(1)
|
Ensembl | 5,343 nt | ||
| mRNA |
ubap2l-203
(1)
|
Ensembl | 5,066 nt | ||
| ncRNA |
ubap2l-003
(1)
|
Ensembl | 726 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-204A24 | ZFIN Curated Data | |
| Encodes | EST | eu902 | Thisse et al., 2005 | |
| Encodes | EST | fb95d09 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001083066 (1) | 5066 nt | ||
| Genomic | GenBank:CR628394 (1) | 242800 nt | ||
| Polypeptide | UniProtKB:A0A8M2B5X1 (1) | 1212 aa |
- Doll, L., Aghaallaei, N., Dick, A.M., Welte, K., Skokowa, J., Bajoghli, B. (2020) A zebrafish model for HAX1-associated congenital neutropenia. Haematologica. 106(5):1311-1320
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Mandriani, B., Castellana, S., Rinaldi, C., Manzoni, M., Venuto, S., Rodriguez-Aznar, E., Galceran, J., Nieto, M.A., Borsani, G., Monti, E., Mazza, T., Merla, G., Micale, L. (2016) Identification of p53-target genes in Danio rerio. Scientific Reports. 6:32474
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Rösel, T.D., Hung, L.H., Medenbach, J., Donde, K., Starke, S., Benes, V., Rätsch, G., and Bindereif, A. (2011) RNA-Seq analysis in mutant zebrafish reveals role of U1C protein in alternative splicing regulation. The EMBO journal. 30(10):1965-1976
- Geisler, R., Rauch, G.J., Baier, H., van Bebber, F., Brobeta, L., Dekens, M.P., Finger, K., Fricke, C., Gates, M.A., Geiger, H., Geiger-Rudolph, S., Gilmour, D., Glaser, S., Gnugge, L., Habeck, H., Hingst, K., Holley, S., Keenan, J., Kirn, A., Knaut, H., Lashkari, D., Maderspacher, F., Martyn, U., Neuhauss, S., Neumann, C., Nicolson, T., Pelegri, F., Ray, R., Rick, J.M., Roehl, H., Roeser, T., Schauerte, H.E., Schier, A.F., Schönberger, U., Schönthaler, H.-B., Schulte-Merker, S., Seydler, C., Talbot, W.S., Weiler, C., Nüsslein-Volhard, C., and Haffter, P. (1999) A radiation hybrid map of the zebrafish genome. Nature Genetics. 23(1):86-89
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