ZFIN ID: ZDB-GENE-060503-164
Gene Name: epidermal growth factor receptor pathway substrate 8b
Gene Symbol: eps8b    Nomenclature History

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Previous Name: si:dkey-287h13.1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to contribute to Rac guanyl-nucleotide exchange factor activity. Predicted to be involved in Rho protein signal transduction; positive regulation of ruffle assembly; and regulation of Rho protein signal transduction. Predicted to localize to the ruffle membrane.
Genome Resources: Alliance (1),  Gene:564779 (1),  Ensembl(GRCz11):ENSDARG00000069011 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa8563 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32197 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH eps8b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH eps8b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of ruffle assembly (more)
    Cellular Component plasma membrane (more)
    Molecular Function actin binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001452 SH3 domain
    Homologous_superfamily IPR013761 Sterile alpha motif/pointed domain superfamily
    Homologous_superfamily IPR036028 SH3-like domain superfamily
    Family IPR039801 Epidermal growth factor receptor kinase substrate 8-like
    Domain IPR041418 SAM domain
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA eps8b-201 (1)    Ensembl 793
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM eps8b No data available
    MARKER RELATIONSHIPS
    eps8b Contained in: [BAC] CH73-193M8 (1), DKEY-287H13 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_021467783 (1)
    Genomic GenBank:BX571817 (1) 167381 bp
    Select Tool
    Polypeptide UniProtKB:F1R3J5 (1) 242 aa
    Sequence Information (all 8)
    ORTHOLOGY for eps8b ( Chr: 18 )
    CITATIONS (12)