ZFIN ID: ZDB-GENE-060503-14
Gene Name: fibroblast growth factor receptor 1b
Gene Symbol: fgfr1b    Nomenclature History

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Previous Name: si:ch211-180b9.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have fibroblast growth factor binding activity and fibroblast growth factor-activated receptor activity. Involved in fibroblast growth factor receptor signaling pathway and post-anal tail morphogenesis. Predicted to localize to integral component of plasma membrane and receptor complex. Is expressed in several structures, including basal plate midbrain region; forebrain neural keel; forebrain neural rod; head; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including Jackson-Weiss syndrome; bone disease (multiple); cleft lip; hematologic cancer (multiple); and hypogonadotropic hypogonadism (multiple). Orthologous to human FGFR1 (fibroblast growth factor receptor 1).
Genome Resources: Alliance (1),  Gene:567905 (1),  Ensembl(GRCz11):ENSDARG00000011190 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la017590Tg Transgenic Insertion Unknown Unknown DNA
sa13288 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14213 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-fgfr1b
    1
    MO1-fgfr1b N/A 3
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH fgfr1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hypogonadotropic hypogonadism 2 with or without anosmia Alliance Hypogonadotropic hypogonadism 2 with or without anosmia 147950
    Jackson-Weiss syndrome Alliance Jackson-Weiss syndrome 123150
    osteoglophonic dysplasia Alliance Osteoglophonic dysplasia 166250
    Pfeiffer syndrome Alliance Pfeiffer syndrome 101600
    Encephalocraniocutaneous lipomatosis, somatic mosaic 613001
    Hartsfield syndrome 615465
    Trigonocephaly 1 190440
    DISEASE ASSOCIATED WITH fgfr1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process fibroblast growth factor receptor signaling pathway (more)
    Cellular Component integral component of membrane (more)
    Molecular Function protein binding (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fgfr1b-203 (1)    Ensembl 1038
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fgfr1b No data available
    MARKER RELATIONSHIPS
    fgfr1b Contained in: [BAC] CH211-180B9 (1)
    fgfr1b Encodes: [cDNA] cssl:d811 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001161732 (1) 2420 nt
    Genomic GenBank:AL935178 (1) 144027 nt
    Select Tool
    Polypeptide UniProtKB:G1K2P7 (1) 766 aa
    Sequence Information (all 25)
    ORTHOLOGY for fgfr1b ( Chr: 10 )
    CITATIONS (44)