ZFIN ID: ZDB-GENE-060502-2
Gene Name: ALG2 alpha-1,3/1,6-mannosyltransferase
Gene Symbol: alg2    Nomenclature History

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Previous Name: im:7145131

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have alpha-1,3-mannosyltransferase activity and glycolipid mannosyltransferase activity. Predicted to be involved in oligosaccharide-lipid intermediate biosynthetic process and protein glycosylation in endoplasmic reticulum. Localizes to nucleus. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ii and congenital myasthenic syndrome 14. Orthologous to human ALG2 (ALG2 alpha-1,3/1,6-mannosyltransferase).
Genome Resources: Alliance (1),  Gene:403068 (1),  Ensembl(GRCz11):ENSDARG00000070399 (2)
GENE EXPRESSION
All Expression Data: 3 figures from DeRossi et al., 2016
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la012903Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36156 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39101 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH alg2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital disorder of glycosylation Ii Alliance ?Congenital disorder of glycosylation, type Ii 607906
    congenital myasthenic syndrome 14 Alliance Myasthenic syndrome, congenital, 14, with tubular aggregates 616228
    DISEASE ASSOCIATED WITH alg2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein glycosylation (more)
    Cellular Component nucleus (more)
    Molecular Function glycolipid mannosyltransferase activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA alg2-201 (1)    Ensembl 2070
    alg2-202 (1)    Ensembl 727
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM alg2 No data available
    MARKER RELATIONSHIPS
    alg2 Contained in: [Fosmid] CH1073-210A20 (1)
    alg2 Encodes: [EST] IMAGE:7145131 (1)
    [cDNA] MGC:171401 (1), MGC:174066 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001104936 (1) 1898 nt
    Genomic GenBank:CU914485 (1) 30845 nt
    Select Tool
    Polypeptide UniProtKB:F1QPS1 (1) 455 aa
    Sequence Information (all 21)
    ORTHOLOGY for alg2 ( Chr: 16 )
    CITATIONS (29)