ZFIN ID: ZDB-GENE-060427-5
Gene Name: receptor tyrosine kinase-like orphan receptor 2
Gene Symbol: ror2
Location: Chr: 10   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  anatomical structure, brain, whole organism
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Knockdown reagents: MO1-ror2 (1), MO2-ror2 (1), MO3-ror2 (1), MO4-ror2 (1)

Allele Type Mutagen Suppliers
la017614Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la017615Tg Transgenic Insertion DNA
    sa17931 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE
    Data: Fig. 3 from Young et al., 2014
    Observed in: ectoderm cell, ectoderm, extension, eye (all 8) expand

    Phenotype of Human Orthologue OMIM Phenotype ID
    Brachydactyly, type B1 113000
    Robinow syndrome, autosomal recessive 268310
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process convergent extension involved in gastrulation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function protein heterodimerization activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000001 (1)
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR003598 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR013806 (1)
  • InterPro:IPR016247 (1)
  • InterPro:IPR018056 (1)
  • InterPro:IPR020067 (1)
  • InterPro:IPR020635 (1)
  • PROSITE:PS00021 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50038 (1)
  • PROSITE:PS50070 (1)
  • PROSITE:PS50835 (1)
  • Pfam:PF00051 (1)
  • Pfam:PF01392 (1)
  • Pfam:PF07679 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ror2-001 (1) 3990
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ror2 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    ror2 Contained in: [BAC] CH211-67C21 (1) (order this), DKEY-60D5 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA GenBank:EL651268 (1) 927 bp
    Genomic GenBank:CR352227 (1) 168407 bp
    Select Tool
    Polypeptide UniProtKB:E7FCE4 (1) 939 aa
    Sequence Clusters UniGene:81744 (1)
    Sequence Information (all 14)
    OTHER ror2 GENE PAGES
  • Gene:692066 (1)
  • VEGA:OTTDARG00000030774 (1)
  • Ensembl(Zv9):ENSDARG00000076227 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish ror2 10  
    Human ROR2 9 (9q22)
  • OMIM:602337
  • Gene:4920
  • Mouse Ror2 13 ( 27.68 cM)
  • MGI:1347521
  • Gene:26564
  • Orthology Details
    CITATIONS (20)