ZFIN ID: ZDB-GENE-060427-5
Gene Name: receptor tyrosine kinase-like orphan receptor 2
Gene Symbol: ror2
Location: Chr: 10   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  anatomical structure, brain, whole organism
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: la017614Tg, la017615Tg, sa17931
Knockdown reagents: MO1-ror2 (1), MO2-ror2 (1), MO3-ror2 (1), MO4-ror2 (1)
PHENOTYPE
Data: Fig. 3 from Young et al., 2014
Observed in: ectoderm cell, ectoderm, extension, eye (all 8) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Brachydactyly, type B1 113000
Robinow syndrome, autosomal recessive 268310
GENE ONTOLOGY
Ontology GO Term
Biological Process convergent extension involved in gastrulation (more)
Cellular Component integral component of membrane (more)
Molecular Function protein heterodimerization activity (more)
GO Terms (all 15)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000001 (1)
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR003598 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR013806 (1)
  • InterPro:IPR016247 (1)
  • InterPro:IPR018056 (1)
  • InterPro:IPR020067 (1)
  • InterPro:IPR020635 (1)
  • PROSITE:PS00021 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50038 (1)
  • PROSITE:PS50070 (1)
  • PROSITE:PS50835 (1)
  • Pfam:PF00051 (1)
  • Pfam:PF01392 (1)
  • Pfam:PF07679 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ror2-001 (1) 3990
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ror2 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    ror2 Contained in: [BAC] CH211-67C21 (1) (order this), DKEY-60D5 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA GenBank:EL651268 (1) 927 bp
    Genomic GenBank:CR352227 (1) 168407 bp
    Select Tool
    Polypeptide UniProtKB:E7FCE4 (1) 939 aa
    Sequence Clusters UniGene:81744 (1)
    Sequence Information (all 14)
    OTHER ror2 GENE PAGES
  • Gene:692066 (1)
  • VEGA:OTTDARG00000030774 (1)
  • Ensembl(Zv9):ENSDARG00000076227 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish ror2 10  
    Human ROR2 9 (9q22)
  • OMIM:602337
  • Gene:4920
  • Mouse Ror2 13 ( 27.68 cM)
  • MGI:1347521
  • Gene:26564
  • Orthology Details
    CITATIONS (20)