ZFIN ID: ZDB-GENE-060422-1
Gene Name: NUMB endocytic adaptor protein
Gene Symbol: numb    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have cadherin binding activity. Involved in primitive erythrocyte differentiation. Localizes to basolateral plasma membrane and cytoplasm. Is expressed in brain; digestive system; immature eye; neural tube; and neuromast. Orthologous to human NUMB (NUMB endocytic adaptor protein).
Genome Resources: Alliance (1),  Gene:692064 (1),  Ensembl(GRCz11):ENSDARG00000027279 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la027886Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-numb N/A 1
    MO2-numb,numbl N/A 1
    MO3-numb N/A 1
    MO4-numb N/A 1
    MO5-numb N/A 1
    DISEASE ASSOCIATED WITH numb HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH numb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process primitive erythrocyte differentiation (more)
    Cellular Component basolateral plasma membrane (more)
    Molecular Function cadherin binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA numb-201 (1)    Ensembl 2326
    numb-202 (1)    Ensembl 5815
    numb-203 (1)    Ensembl 624
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM numb No data available
    MARKER RELATIONSHIPS
    numb Contained in: [BAC] CH211-168D23 (1)
    [Fosmid] CH1073-40C22 (1)
    numb Encodes: [cDNA] MGC:193921 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001040406 (1) 2359 nt
    Genomic GenBank:CU302376 (1) 135201 nt
    Select Tool
    Polypeptide UniProtKB:B3DG87 (1) 680 aa
    Sequence Information (all 26)
    ORTHOLOGY for numb ( Chr: 17 )
    CITATIONS (29)