Gene
nfixb
- ID
- ZDB-GENE-060421-5000
- Name
- nuclear factor I/Xb
- Symbol
- nfixb Nomenclature History
- Previous Names
-
- zgc:136878
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Marshall-Smith syndrome and Sotos syndrome. Is expressed in midbrain; muscle; and telencephalon. Orthologous to human NFIX (nuclear factor I X).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Marshall-Smith syndrome | Alliance | Marshall-Smith syndrome | 602535 |
| Sotos syndrome 2 | Alliance | Malan syndrome | 614753 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019739 | CTF transcription factor/nuclear factor 1, conserved site |
| Domain | IPR003619 | MAD homology 1, Dwarfin-type |
| Domain | IPR019548 | CTF transcription factor/nuclear factor 1, N-terminal |
| Domain | IPR020604 | CTF transcription factor/nuclear factor 1, DNA-binding domain |
| Family | IPR000647 | CTF transcription factor/nuclear factor 1 |
Domain Details Per Protein
| Protein | Length | CTF transcription factor/nuclear factor 1 | CTF transcription factor/nuclear factor 1, conserved site | CTF transcription factor/nuclear factor 1, DNA-binding domain | CTF transcription factor/nuclear factor 1, N-terminal | MAD homology 1, Dwarfin-type |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3B860
|
562 | |||||
|
UniProtKB:Q1RLS5
|
440 | |||||
|
UniProtKB:A0A8M2BAY5
|
528 | |||||
|
UniProtKB:A0A8M3AXV2
|
530 | |||||
|
UniProtKB:A0A8M3AQD9
|
513 | |||||
|
UniProtKB:A0A8M3AQR1
|
556 | |||||
|
UniProtKB:A0A8M2BBB5
|
536 | |||||
|
UniProtKB:A0A8M3AQR5
|
561 | |||||
|
UniProtKB:A0A8M3B0T9
|
500 | |||||
|
UniProtKB:A0A8M3B863
|
512 | |||||
|
UniProtKB:A0A8M3AXU6
|
574 | |||||
|
UniProtKB:A0A8M3AQD4
|
573 | |||||
|
UniProtKB:A0A8M3B0T6
|
531 |
Interactions and Pathways
No data available
Plasmids
No data available