Gene
polh
- ID
- ZDB-GENE-060421-4949
- Name
- polymerase (DNA directed), eta
- Symbol
- polh Nomenclature History
- Previous Names
-
- fc50a12
- wu:fc50a12
- zgc:136881
- zgc:152642
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to have DNA-directed DNA polymerase activity. Predicted to be involved in error-prone translesion synthesis and response to radiation. Predicted to localize to nucleus; replication fork; and site of double-strand break. Human ortholog(s) of this gene implicated in xeroderma pigmentosum variant type. Orthologous to human POLH (DNA polymerase eta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| xeroderma pigmentosum variant type | Alliance | Xeroderma pigmentosum, variant type | 278750 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001126 | UmuC domain |
| Domain | IPR017961 | DNA polymerase, Y-family, little finger domain |
| Domain | IPR041298 | DNA polymerase eta, ubiquitin-binding zinc finger |
| Family | IPR052230 | DNA polymerase eta |
| Homologous_superfamily | IPR036775 | DNA polymerase, Y-family, little finger domain superfamily |
| Homologous_superfamily | IPR043128 | Reverse transcriptase/Diguanylate cyclase domain |
| Homologous_superfamily | IPR043502 | DNA/RNA polymerase superfamily |
Domain Details Per Protein
| Protein | Length | DNA polymerase eta | DNA polymerase eta, ubiquitin-binding zinc finger | DNA polymerase, Y-family, little finger domain | DNA polymerase, Y-family, little finger domain superfamily | DNA/RNA polymerase superfamily | Reverse transcriptase/Diguanylate cyclase domain | UmuC domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1Q7Z9
|
749 |
Interactions and Pathways
No data available
Plasmids
No data available