Gene

polh

ID
ZDB-GENE-060421-4949
Name
polymerase (DNA directed), eta
Symbol
polh Nomenclature History
Previous Names
  • fc50a12
  • wu:fc50a12
  • zgc:136881
  • zgc:152642
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have DNA-directed DNA polymerase activity. Predicted to be involved in error-prone translesion synthesis and response to radiation. Predicted to localize to nucleus; replication fork; and site of double-strand break. Human ortholog(s) of this gene implicated in xeroderma pigmentosum variant type. Orthologous to human POLH (DNA polymerase eta).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With polh Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
xeroderma pigmentosum variant type Alliance Xeroderma pigmentosum, variant type 278750
Associated With polh Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001126 UmuC domain
Domain IPR017961 DNA polymerase, Y-family, little finger domain
Domain IPR041298 DNA polymerase eta, ubiquitin-binding zinc finger
Homologous_superfamily IPR036775 DNA polymerase, Y-family, little finger domain superfamily
Homologous_superfamily IPR043128 Reverse transcriptase/Diguanylate cyclase domain
Homologous_superfamily IPR043502 DNA/RNA polymerase superfamily
Domain Details Per Protein
Protein Length DNA polymerase eta, ubiquitin-binding zinc finger DNA polymerase, Y-family, little finger domain DNA polymerase, Y-family, little finger domain superfamily DNA/RNA polymerase superfamily Reverse transcriptase/Diguanylate cyclase domain UmuC domain
UniProtKB:F1Q7Z9 749
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations