Gene

irf1a

ID
ZDB-GENE-060421-4031
Name
interferon regulatory factor 1a
Symbol
irf1a Nomenclature History
Previous Names
  • IRF11 (1)
  • irf1 (1)
  • zgc:136945
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in immune system process. Predicted to localize to nucleus. Is expressed in several structures, including blood; digestive system; eye; immune system; and integument. Human ortholog(s) of this gene implicated in asthma; gastric adenocarcinoma; and lung non-small cell carcinoma. Orthologous to human IRF1 (interferon regulatory factor 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With irf1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
lung cancer Alliance Nonsmall cell lung cancer, somatic 211980
stomach cancer Alliance Gastric cancer, somatic 613659
Myelodysplastic syndrome, preleukemic
Myelogenous leukemia, acute
Associated With irf1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019817 Interferon regulatory factor, conserved site
Domain IPR001346 Interferon regulatory factor DNA-binding domain
Family IPR017431 Interferon regulatory factor-1/2
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Interferon regulatory factor-1/2 Interferon regulatory factor, conserved site Interferon regulatory factor DNA-binding domain Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:F1QPF2 251
UniProtKB:Q1RLP9 251
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations