ZFIN ID: ZDB-GENE-060421-4031
Gene Name: interferon regulatory factor 1a
Gene Symbol: irf1a    Nomenclature History

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Previous Names: IRF11 (1), irf1 (1), zgc:136945

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in immune system process. Predicted to localize to nucleus. Is expressed in several structures, including blood; digestive system; eye; immune system; and integument. Human ortholog(s) of this gene implicated in asthma; gastric adenocarcinoma; and lung non-small cell carcinoma. Orthologous to human IRF1 (interferon regulatory factor 1).
Genome Resources: Alliance (1),  Gene:678604 (1),  Ensembl(GRCz11):ENSDARG00000043492 (2)
GENE EXPRESSION
All Expression Data: 6 figures from 5 publications
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb134 Small Deletion Exon 1 Frameshift, Premature Stop CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • ihb194 Insertion Exon 1 Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-irf1a 2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH irf1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    lung cancer Alliance Nonsmall cell lung cancer, somatic 211980
    stomach cancer Alliance Gastric cancer, somatic 613659
    Myelodysplastic syndrome, preleukemic
    Myelogenous leukemia, acute
    DISEASE ASSOCIATED WITH irf1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA irf1a-201 (1)    Ensembl 1439
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM irf1a No data available
    MARKER RELATIONSHIPS
    irf1a Contained in: [Fosmid] ZFOS-1762D12 (1)
    irf1a Encodes: [cDNA] MGC:136945 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001040352 (1) 1480 nt
    Genomic GenBank:CU694274 (1) 41491 nt
    Select Tool
    Polypeptide UniProtKB:F1QPF2 (1) 251 aa
    Sequence Information (all 12)
    ORTHOLOGY for irf1a ( Chr: 13 )
    CITATIONS (37)