ZFIN ID: ZDB-GENE-060421-1
Gene Name: MPL proto-oncogene, thrombopoietin receptor
Gene Symbol: mpl
Sequence Ontology ID : SO:0000704

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Previous Names: c-mpl (1), mpll, tpor (1)

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(Including Attributions)
Location: Chr: 6 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have nucleic acid binding activity; involved in thrombocyte differentiation; predicted to localize to the integral component of membrane; used to study congenital amegakaryocytic  ...
GENE EXPRESSION
All Expression Data: 8 figures from 8 publications
Wild-type Stages, Structures: Hatching:Pec-fin (60.0h-72.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa881 Point Mutation Unknown Premature Stop ENU
sa20736 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26776 Point Mutation Unknown Splice Site ENU
    sm10 Indel Exon 3 Premature Stop TALEN
    Targeting reagents:
    PHENOTYPE
    Data: 5 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH mpl HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    congenital amegakaryocytic thrombocytopenia Thrombocytopenia, congenital amegakaryocytic 604498
    essential thrombocythemia Thrombocythemia 2 601977
    myelofibrosis Myelofibrosis with myeloid metaplasia, somatic 254450
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process thrombocyte differentiation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function nucleic acid binding (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR003961 (1)
  • InterPro:IPR013087 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR015152 (1)
  • InterPro:IPR036116 (1)
  • PROSITE:PS00028 (1)
  • PROSITE:PS50853 (1)
  • Pfam:PF09067 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA mpl-202 (1) 2175
    mpl-203 (1) 1840
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM mpl
    MARKER RELATIONSHIPS
    mplContained in: [BAC] CH211-175H18 (1) (order this)
    mplEncodes: [cDNA] MGC:193835 (1) (order this), MGC:193839 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001003858 (1) 2086bp
    Genomic GenBank:CR854855 (1) 144317bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8PZ02 (1) 655aa
    Sequence Clusters UniGene:92531 (1)
    Sequence Information (all 27)
    OTHER mpl GENE PAGES
  • Alliance (1)
  • Gene:445381 (1)
  • VEGA:OTTDARG00000023590 (1)
  • ORTHOLOGY for mpl (Chr: 6)
    CITATIONS (29)