Gene

mpl

ID
ZDB-GENE-060421-1
Name
MPL proto-oncogene, thrombopoietin receptor
Symbol
mpl Nomenclature History
Previous Names
  • c-mpl (1)
  • mpll
  • tpor (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Involved in thrombocyte differentiation. Predicted to localize to integral component of membrane. Is expressed in blood; nucleate erythrocyte; thrombocyte; and ventral wall of dorsal aorta. Used to study congenital amegakaryocytic thrombocytopenia. Human ortholog(s) of this gene implicated in congenital amegakaryocytic thrombocytopenia; essential thrombocythemia; myelofibrosis; thrombocytopenia; and thrombocytosis. Orthologous to human MPL (MPL proto-oncogene, thrombopoietin receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mpl Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital amegakaryocytic thrombocytopenia Alliance Thrombocytopenia, congenital amegakaryocytic 604498
essential thrombocythemia Alliance Thrombocythemia 2 601977
myelofibrosis Alliance Myelofibrosis with myeloid metaplasia, somatic 254450
Associated With mpl Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003961 Fibronectin type III
Domain IPR013087 Zinc finger C2H2-type
Domain IPR015152 Growth hormone/erythropoietin receptor, ligand binding
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Domain Details Per Protein
Protein Length Fibronectin type III Fibronectin type III superfamily Growth hormone/erythropoietin receptor, ligand binding Immunoglobulin-like fold Zinc finger C2H2-type
UniProtKB:I3ITG5 613
UniProtKB:A0A2R8PZ02 655
UniProtKB:A8WHB2 655
UniProtKB:A8WHA0 641
UniProtKB:Q6EIY6 614
UniProtKB:F1QDB2 614
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations