ZFIN ID: ZDB-GENE-060314-2
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Gene Name: solute carrier family 6 member 4b
Gene Symbol: slc6a4b    Nomenclature History

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Previous Name: sertb (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have serotonin binding activity and serotonin:sodium symporter activity. Predicted to be involved in serotonin uptake. Predicted to localize to the neuron projection and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; anxiety disorder (multiple); autistic disorder; dyspepsia; and heart disease (multiple). Is expressed in nervous system. Orthologous to human SLC6A4 (solute carrier family 6 member 4).
Genome Resources: Alliance (1),  Gene:664770 (1),  Ensembl(GRCz11):ENSDARG00000057017 (1)
GENE EXPRESSION
All Expression Data: 5 figures from 4 publications
Wild-type Stages, Structures: Hatching:Pec-fin (60.0h-72.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa15666 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa20377 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa33568 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa40389 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-slc6a4b N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH slc6a4b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    anxiety disorder Alliance {Anxiety-related personality traits} 607834
    {Obsessive-compulsive disorder} 164230
    DISEASE ASSOCIATED WITH slc6a4b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process serotonin uptake (more)
    Cellular Component integral component of membrane (more)
    Molecular Function serotonin:sodium symporter activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000175 Sodium:neurotransmitter symporter
    Homologous_superfamily IPR037272 Sodium:neurotransmitter symporter superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA slc6a4b-201 (1)    Ensembl 1852
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM slc6a4b No data available
    MARKER RELATIONSHIPS
    slc6a4b Contained in: [BAC] DKEY-234H16 (1) (order this), RP71-1C23 (1)
    slc6a4b Encodes: [cDNA] MGC:194743 (1), MGC:194776 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001177459 (1) 1852 bp
    Select Tool
    Genomic GenBank:BX323811 (1) 204094 bp Blast at MegaBLAST
    Polypeptide UniProtKB:B3DJ31 (1) 591 aa
    Select Tool
    Sequence Information (all 15)
    ORTHOLOGY for slc6a4b ( Chr: 5 )
    CITATIONS (34)