Gene
slc6a4b
- ID
- ZDB-GENE-060314-2
- Name
- solute carrier family 6 member 4b
- Symbol
- slc6a4b Nomenclature History
- Previous Names
-
- sertb (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have serotonin binding activity and serotonin:sodium symporter activity. Predicted to be involved in serotonin uptake and sodium ion transmembrane transport. Predicted to localize to integral component of plasma membrane and neuron projection. Is expressed in nervous system. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; alexithymia; anxiety disorder (multiple); heart disease (multiple); and mental depression (multiple). Orthologous to human SLC6A4 (solute carrier family 6 member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| anxiety disorder | Alliance | {Anxiety-related personality traits} | 607834 |
| {Obsessive-compulsive disorder} | 164230 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Sodium:neurotransmitter symporter | Sodium:neurotransmitter symporter superfamily |
|---|---|---|---|
|
UniProtKB:B3DJ31
|
591 | ||
|
UniProtKB:Q1WGB4
|
361 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
slc6a4b-201
(1)
|
1852 nt |
Interactions and Pathways
No data available
Plasmids
No data available