ZFIN ID: ZDB-GENE-060314-1
Gene Name: solute carrier family 6 member 4a
Gene Symbol: slc6a4a    Nomenclature History

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Previous Name: serta (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Exhibits drug binding activity and serotonin:sodium symporter activity. Involved in serotonin transport. Predicted to localize to the neuron projection and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; anxiety disorder (multiple); autistic disorder; dyspepsia; and heart disease (multiple). Is expressed in brain; pharynx; and spinal cord. Orthologous to human SLC6A4 (solute carrier family 6 member 4).
Genome Resources: Alliance (1),  Gene:664719 (1),  Ensembl(GRCz11):ENSDARG00000061165 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la019290Tg Transgenic Insertion Unknown Unknown DNA
sa17033 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-slc6a4a N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH slc6a4a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    anxiety disorder Alliance {Anxiety-related personality traits} 607834
    {Obsessive-compulsive disorder} 164230
    DISEASE ASSOCIATED WITH slc6a4a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process serotonin transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function drug binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000175 Sodium:neurotransmitter symporter
    Homologous_superfamily IPR037272 Sodium:neurotransmitter symporter superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA slc6a4a-201 (1)    Ensembl 2166
    ncRNA slc6a4a-002 (1)    Ensembl 540
    slc6a4a-003 (1)    Ensembl 539
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM slc6a4a No data available
    MARKER RELATIONSHIPS
    slc6a4a Contained in: [BAC] CH211-225B7 (1)
    slc6a4a Encodes: [cDNA] MGC:195071 (1), MGC:195093 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001039972 (1) 2168 bp
    Genomic GenBank:BX088540 (1) 176569 bp
    Select Tool
    Polypeptide UniProtKB:Q1WGB5 (1) 646 aa
    Sequence Information (all 32)
    ORTHOLOGY for slc6a4a ( Chr: 15 )
    CITATIONS (57)