ZFIN ID: ZDB-GENE-060312-44
Gene Name: neurofilament, light polypeptide b
Gene Symbol: neflb    Nomenclature History

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Previous Names: nefl (1), zgc:136626 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have structural molecule activity. Involved in hindbrain development; negative regulation of neuron apoptotic process; and spinal cord development. Predicted to localize to neurofilament. Is expressed in nervous system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease (multiple); amyotrophic lateral sclerosis; and invasive ductal carcinoma. Orthologous to human NEFL (neurofilament light).
Genome Resources: Alliance (1),  Gene:664698 (1),  Ensembl(GRCz11):ENSDARG00000012426 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa13719 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34292 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-neflb N/A 1
    DISEASE ASSOCIATED WITH neflb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Charcot-Marie-Tooth disease dominant intermediate G Alliance Charcot-Marie-Tooth disease, dominant intermediate G 617882
    Charcot-Marie-Tooth disease type 1F Alliance Charcot-Marie-Tooth disease, type 1F 607734
    Charcot-Marie-Tooth disease type 2E Alliance Charcot-Marie-Tooth disease, type 2E 607684
    DISEASE ASSOCIATED WITH neflb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hindbrain development (more)
    Cellular Component intermediate filament (more)
    Molecular Function structural molecule activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA neflb-201 (1)    Ensembl 2221
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM neflb No data available
    MARKER RELATIONSHIPS
    neflb Contained in: [BAC] CH73-347J20 (1), CH211-255G12 (1)
    neflb Encodes: [cDNA] MGC:136626 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001039838 (1) 2240 nt
    Genomic GenBank:AL954310 (1) 156407 nt
    Select Tool
    Polypeptide UniProtKB:B0R1B8 (1) 579 aa
    Sequence Information (all 14)
    ORTHOLOGY for neflb ( Chr: 8 )
    CITATIONS (22)